体外照射的人外周血淋巴细胞中染色体畸变的剂量率依赖性

Dose-rate dependence of chromosome aberrations in human peripheral blood lymphocytes irradiated in vitro.

作者信息

Konecná H, Kalina I

机构信息

Department of Medical Biology, Faculty of Medicine, P.J. Safárik University, Kosice.

出版信息

Folia Biol (Praha). 1987;33(5):301-6.

Abstract

Dose response relationships were studied in dicentric chromosomes in human peripheral blood lymphocytes exposed in vitro to 60Co gamma-rays in accumulated doses from 0.10 to 4.0 Gy at dose rates 1.0, 0.1, 0.01, and 0.001 Gy/min. The coefficients for the linear, quadratic and linear-quadratic relationships were calculated by the fitting method of least squares. It was found that the linear-quadratic model y = aD + bD2 was most suitable for the dose rates used. The effect of dose rate was manifested in such a way that at accumulated dose of 2.0 Gy the frequency of dicentric chromosomes was decreased by more than 50% if the dose was applied in 33 h than when it was given in 2, 20 or 200 min.

摘要

研究了体外暴露于60Coγ射线的人外周血淋巴细胞中双着丝粒染色体的剂量反应关系，累积剂量为0.10至4.0 Gy，剂量率分别为1.0、0.1、0.01和0.001 Gy/min。通过最小二乘法拟合计算线性、二次和线性二次关系的系数。结果发现，线性二次模型y = aD + bD2最适合所使用的剂量率。剂量率的影响表现为，在累积剂量为2.0 Gy时，如果剂量在33小时内给予，双着丝粒染色体的频率比在2、20或200分钟内给予时降低超过50%。

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