Fabry L, Lemaire M
C R Seances Soc Biol Fil. 1985;179(2):236-42.
The production of chromosome aberrations in vivo has been studied in lymphocytes from a patient undergoing a wholebody treatment with gamma-radiation up to a cumulative dose of 1.4 Gy. These results were compared with the observations performed on whole blood samples irradiated in vitro with doses from 0.05 up to 2 Gy of gamma-rays. The frequency of chromosome aberrations, particularly the dicentrics, was found to be similar in vivo and in vitro. The yield of dicentrics could be best related to the dose by using a linear-quadratic model in both cases, the ratio of the coefficients a/b being of 0.56 and 0.69 Gy, respectively in vivo and in vitro. These observations confirm that in vitro dose response curves may be used to evaluate accurately an in vivo absorbed dose.
对一名接受全身γ射线照射、累积剂量达1.4 Gy的患者的淋巴细胞进行了体内染色体畸变产生情况的研究。将这些结果与用0.05至2 Gyγ射线体外照射全血样本的观察结果进行了比较。发现体内和体外染色体畸变的频率，尤其是双着丝粒的频率相似。在两种情况下，通过使用线性二次模型，双着丝粒的产额与剂量的关系最为密切，体内和体外的系数a/b之比分别为0.56和0.69 Gy。这些观察结果证实，体外剂量反应曲线可用于准确评估体内吸收剂量。
