Motamedi Mandana, Moini Ashraf, Maajani Khadije, Maleki-Hajiagha Arezoo, Alipour Sadaf
Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran.
Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
J Reprod Infertil. 2023 Jan-Mar;24(1):58-62. doi: 10.18502/jri.v24i1.11910.
Fibroadenoma (FA) and infertility can share common risk factors and probably common underlying pathophysiology, but yet there is no study evaluating the prevalence of FA in infertile women. Therefore, the aim of in the present study, the purpose was evaluating the association of FA and infertility for the first time.
This short communication is a secondary analysis of a primary study that was performed in Arash Women's Hospital, Tehran, Iran. Participants were selected among reproductive-aged women with a history of infertility as the case and women without infertility as the control group. The criteria for diagnosis of FA were histopathologic assessment for lumps 1 in size or larger, and a typical ultrasound image for smaller lumps. Assisted reproductive technology (ART) was defined as any previous history of undergoing ovulation stimulation, intrauterine insemination, intracytoplasmic sperm injection, or in vitro fertilization.
Overall, 155 cases with a mean age of 39.2±6.9, and 167 controls with a mean age of 43.08±8.3 were included (p=0.0001). Interestingly, the incidence of FA was lower in the case group (18.7% . 25.7%), however, the difference was not statistically significant (p=0.13). Also, logistic regression analysis showed that the chance for an infertile woman who undergoes ART to get FA is 1.7 times higher in comparison to non-ART group, although the difference was not significant (p=0.21).
Infertility and ART were not associated with increased risk of FA; however, larger prospective studies should be conducted in the future in order to achieve conclusive results.
纤维瘤（FA）与不孕症可能存在共同的风险因素，并且可能有共同的潜在病理生理学，但尚无研究评估不孕女性中FA的患病率。因此，在本研究中，目的是首次评估FA与不孕症之间的关联。
本简短通讯是对在伊朗德黑兰阿拉什妇女医院进行的一项主要研究的二次分析。参与者从有不孕史的育龄妇女中选取作为病例组，无不孕史的妇女作为对照组。FA的诊断标准为：对于直径1厘米或更大的肿块进行组织病理学评估，对于较小的肿块采用典型的超声图像。辅助生殖技术（ART）定义为既往有过排卵刺激、宫腔内人工授精、卵胞浆内单精子注射或体外受精的任何病史。
总体而言，纳入了155例平均年龄为39.2±6.9岁的病例和167例平均年龄为43.08±8.3岁的对照（p = 0.0001）。有趣的是，病例组中FA的发生率较低（18.7%对25.7%），然而，差异无统计学意义（p = 0.13）。此外，逻辑回归分析显示，接受ART的不孕女性患FA的几率比未接受ART的组高1.7倍，尽管差异不显著（p = 0.21）。
不孕症和ART与FA风险增加无关；然而，未来应进行更大规模的前瞻性研究以得出确凿结果。
