Andarieh Maryam Ghanbari, Delavar Mouloud Agajani, Moslemi Dariush, Ahmadi Mahmoud Haji, Zabihi Ebrahim, Esmaeilzadeh Sedighe
Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Science, Babol, Iran.
Cancer Research Center, Babol University of Medical Sciences, Babol, Iran.
J Cancer Res Ther. 2019 Jul-Sep;15(5):976-980. doi: 10.4103/jcrt.JCRT_905_16.
Breast cancer is the most common cancer in women worldwide and its prevalence is increasing.
The aim of this study was to investigate the extent to which a history of infertility can present as risk factors for breast cancer.
This was a hospital-based case-control study.
In this study, 1177 women with breast cancer were participated for assessing the risk for this cancer. The control was 1204 women with self-reported free-cancer history who were matched in terms of age and residence.
Using logistic regression, it was examined whether infertility is a risk factor of case-control status in addition to marriage age, menarche age, body mass index, number of pregnancies, family history of breast cancer, and previous oral contraceptive use. The data were considered significant at P ≤ 0.05.
Infertility history was reported in 12.5% (n = 147) of the cases and 5.8% (n = 70) of the controls. Infertility history was a relevant risk for case-control study in addition to other risk factors (odds ratio: 2.43; 95% confidence interval, 3.34-1.77).
This study found that infertility may be as the main risk factor for breast cancer in Iranian women, therefore, doing breast screening in women who have one or more risk factors, must receive more emphasis.
乳腺癌是全球女性中最常见的癌症，其发病率正在上升。
本研究的目的是调查不孕史作为乳腺癌危险因素的程度。
这是一项基于医院的病例对照研究。
在本研究中，1177名乳腺癌女性参与评估患该癌症的风险。对照组为1204名自我报告无癌症病史的女性，她们在年龄和居住地方面进行了匹配。
使用逻辑回归分析，除了结婚年龄、初潮年龄、体重指数、怀孕次数、乳腺癌家族史和以前使用口服避孕药情况外，还检验了不孕是否是病例对照状态的危险因素。数据在P≤0.05时被认为具有统计学意义。
12.5%（n = 147）的病例报告有不孕史，5.8%（n = 70）的对照有不孕史。除其他危险因素外，不孕史是病例对照研究的一个相关危险因素（比值比：2.43；95%置信区间，3.34 - 1.77）。
本研究发现不孕可能是伊朗女性乳腺癌的主要危险因素，因此，对有一个或多个危险因素的女性进行乳房筛查必须得到更多重视。
