评估血清鸢尾素水平作为 2 型糖尿病患者血管内皮功能障碍的标志物。
Evaluation of serum levels of Irisin as a marker of endothelial dysfunction in patients with type 2 diabetes mellitus.
机构信息
Internal Medicine Department at Faculty of Medicine, Beni Suef University, Beni Suef, Egypt.
Internal Medicine Department at Icahn School of Medicine at Mount Sinai, NYC Health+Hospitals, Queens, New York, USA.
出版信息
Endocrinol Diabetes Metab. 2023 May;6(3):e403. doi: 10.1002/edm2.403. Epub 2023 Mar 14.
INTRODUCTION
Insulin resistance and obesity have been associated with irisin, a protein in fat cells. The levels of irisin in patients with type 2 diabetes mellitus (T2DM) were significantly lower than those in non-diabetics. This study aimed to examine the relationship between serum irisin levels and endothelial dysfunction in patients with T2DM.
METHODS
There were 90 participants in this study. We matched 65 patients with T2DM with 25 healthy control participants. A series of tests were performed on the participants, including fasting blood glucose, 2 hours postprandial blood glucose, glycated haemoglobin, triglycerides (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), TG/HDL-C ratio and albumin/creatinine ratio. In addition to measuring high-sensitivity C-reactive protein (hs-CRP). Enzyme-linked immunosorbent assay (ELISA) technique was used for estimating irisin concentrations.
RESULTS
Flow-mediated dilation (FMD) was significantly lower in patients with T2DM; however, there was a non-statistically significant difference between healthy controls and patients with T2DM regarding serum Irisin level. CRP and LDL levels were inversely correlated with circulating irisin levels. In a stepwise regression analysis, only the hs-CRP and LDL were statistically significant in predicting irisin level.
CONCLUSIONS
In patients with T2DM, serum levels of irisin were inversely correlated with hyperglycaemia, body mass index and per cent body fat; this suggests that detecting irisin levels early can prevent cardiovascular diseases from progressing. According to the study results, serum irisin serves as a predictive marker for early cardiovascular disease, thus preventing the disease from progressing. There is a need for further research in order to understand how irisin contributes to the development of atherosclerosis and the development of diabetic complications.
简介
胰岛素抵抗和肥胖与脂肪细胞中的一种蛋白质鸢尾素有关。2 型糖尿病（T2DM）患者的鸢尾素水平明显低于非糖尿病患者。本研究旨在探讨 T2DM 患者血清鸢尾素水平与血管内皮功能障碍的关系。
方法
本研究共纳入 90 名参与者。我们匹配了 65 名 T2DM 患者和 25 名健康对照组参与者。对参与者进行了一系列测试，包括空腹血糖、餐后 2 小时血糖、糖化血红蛋白、甘油三酯（TG）、总胆固醇、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、TG/HDL-C 比值和白蛋白/肌酐比值。此外，还测量了高敏 C 反应蛋白（hs-CRP）。酶联免疫吸附试验（ELISA）技术用于估计鸢尾素浓度。
结果
T2DM 患者的血流介导扩张（FMD）明显降低；然而，健康对照组和 T2DM 患者之间的血清鸢尾素水平无统计学差异。CRP 和 LDL 水平与循环鸢尾素水平呈负相关。在逐步回归分析中，只有 hs-CRP 和 LDL 对预测鸢尾素水平具有统计学意义。
结论
在 T2DM 患者中，血清鸢尾素水平与高血糖、体重指数和体脂百分比呈负相关；这表明早期检测鸢尾素水平可以防止心血管疾病的进展。根据研究结果，血清鸢尾素可作为早期心血管疾病的预测标志物，从而防止疾病进展。需要进一步研究以了解鸢尾素如何导致动脉粥样硬化的发展和糖尿病并发症的发生。
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