一种用于活细胞和斑马鱼中线粒体粘度和 FA 双重成像的 NIR 荧光探针。
A NIR fluorescent probe for dual imaging of mitochondrial viscosity and FA in living cells and zebrafish.
机构信息
Department of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu 610039, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu 610091, China.
出版信息
Analyst. 2023 Mar 27;148(7):1437-1441. doi: 10.1039/d2an01628a.
Formaldehyde (FA) and viscosity play multiple roles in human health and diseases, and viscosity has great regional differences due to the diversity of subcellular organelles. However, it is challenging to achieve dual detection of viscosity and FA in subcellular organelles. Herein, we developed a near infrared (NIR) fluorescent probe FA-Cy, which can simultaneously monitor the viscosity and FA concentration of mitochondria in living cells. The probe could detect mitochondrial viscosity and exogenous and endogenous FA in living cells and zebrafish.
甲醛（FA）和粘度在人类健康和疾病中扮演着多种角色，并且由于亚细胞器的多样性，粘度具有很大的区域差异。然而，在亚细胞器中实现粘度和 FA 的双重检测具有挑战性。在此，我们开发了一种近红外（NIR）荧光探针 FA-Cy，它可以同时监测活细胞中线粒体的粘度和 FA 浓度。该探针可以检测活细胞和斑马鱼中线粒体的粘度以及外源性和内源性 FA。
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