UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis.
作者信息
Moon Jong-Seok, Lee Seonmin, Park Mi-Ae, Siempos Ilias I, Haslip Maria, Lee Patty J, Yun Mijin, Kim Chun K, Howrylak Judie, Ryter Stefan W, Nakahira Kiichi, Choi Augustine Mk
出版信息
J Clin Invest. 2023 Mar 15;133(6):e169986. doi: 10.1172/JCI169986.
Abstract
摘要
相似文献
1
UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis.解偶联蛋白2诱导的脂肪酸合酶在脓毒症期间促进NLRP3炎性小体激活。
J Clin Invest. 2023 Mar 15;133(6):e169986. doi: 10.1172/JCI169986.
2
UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis.脓毒症期间，UCP2诱导的脂肪酸合酶促进NLRP3炎性小体激活。
J Clin Invest. 2015 Feb;125(2):665-80. doi: 10.1172/JCI78253. Epub 2015 Jan 9.
3
Uncoupling Protein 2 Deficiency Enhances NLRP3 Inflammasome Activation Following Hyperglycemia-Induced Exacerbation of Cerebral Ischemia and Reperfusion Damage In Vitro and In Vivo.解偶联蛋白 2 缺乏增强高血糖诱导的体外和体内脑缺血再灌注损伤加重后的 NLRP3 炎症小体激活。
Neurochem Res. 2021 Jun;46(6):1359-1371. doi: 10.1007/s11064-021-03270-9. Epub 2021 Mar 18.
4
Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury.香叶基香叶基二磷酸合酶 1 敲低通过促进脓毒症诱导的急性肺损伤中的自噬来抑制 NLRP3 炎性体活性。
Int Immunopharmacol. 2021 Nov;100:108106. doi: 10.1016/j.intimp.2021.108106. Epub 2021 Sep 13.
5
[Soluble Uric Acid Activates NLRP3 Inflammasome in Myocardial Cells Through Down-regulating UCP2].[可溶性尿酸通过下调解偶联蛋白2激活心肌细胞中的NLRP3炎性小体]
Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Jul;49(4):512-517.
6
MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2.微小 RNA-133a-1 通过解偶联蛋白-2 调节炎症小体的激活。
Biochem Biophys Res Commun. 2013 Sep 27;439(3):407-12. doi: 10.1016/j.bbrc.2013.08.056. Epub 2013 Aug 27.
7
Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression.解偶联蛋白2对星形胶质细胞中NLRP3炎性小体的调节及其在抑郁症中的意义
Redox Biol. 2016 Oct;9:178-187. doi: 10.1016/j.redox.2016.08.006. Epub 2016 Aug 18.
8
Arachidonic acid activates NLRP3 inflammasome in MDSCs via FATP2 to promote post-transplant tumour recurrence in steatotic liver grafts.花生四烯酸通过脂肪酸转运蛋白2（FATP2）激活骨髓来源的抑制性细胞（MDSCs）中的NLRP3炎性小体，以促进脂肪变性肝移植中移植后肿瘤复发。
JHEP Rep. 2023 Aug 22;5(12):100895. doi: 10.1016/j.jhepr.2023.100895. eCollection 2023 Dec.
9
Tangeretin attenuates acute lung injury in septic mice by inhibiting ROS-mediated NLRP3 inflammasome activation via regulating PLK1/AMPK/DRP1 signaling axis.川陈皮素通过调控 PLK1/AMPK/DRP1 信号轴抑制 ROS 介导的 NLRP3 炎性小体激活减轻脓毒症小鼠急性肺损伤。
Inflamm Res. 2024 Jan;73(1):47-63. doi: 10.1007/s00011-023-01819-8. Epub 2023 Dec 26.
10
Cardiac fibroblasts contribute to myocardial dysfunction in mice with sepsis: the role of NLRP3 inflammasome activation.心肌成纤维细胞在脓毒症小鼠中导致心肌功能障碍：NLRP3炎性小体激活的作用
PLoS One. 2014 Sep 12;9(9):e107639. doi: 10.1371/journal.pone.0107639. eCollection 2014.
引用本文的文献
1
Inflammasome Activation and Neutrophil Extracellular Traps in Atherosclerosis.动脉粥样硬化中的炎性小体激活与中性粒细胞胞外诱捕网
J Atheroscler Thromb. 2025 May 1;32(5):535-549. doi: 10.5551/jat.RV22033. Epub 2025 Jan 18.
2
Cellular metabolism changes in atherosclerosis and the impact of comorbidities.动脉粥样硬化中的细胞代谢变化及合并症的影响。
Front Cell Dev Biol. 2024 Aug 12;12:1446964. doi: 10.3389/fcell.2024.1446964. eCollection 2024.
3
Causal relationships between lung cancer and sepsis: a genetic correlation and multivariate mendelian randomization analysis.肺癌与脓毒症之间的因果关系：一项遗传相关性及多变量孟德尔随机化分析
Front Genet. 2024 Jun 28;15:1381303. doi: 10.3389/fgene.2024.1381303. eCollection 2024.
Zotero 插件