Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Division of Restorative Dentistry, Endodontics, Periodontology and Prosthodontics, Department of Dental Medicine and Oral Health, Medical University of Graz, Graz, Austria.
J Periodontal Res. 2023 Jun;58(3):621-633. doi: 10.1111/jre.13111. Epub 2023 Mar 15.
Periodontal disease occurs frequently in patients with limited cutaneous systemic sclerosis (lcSSc) while data about underlying pathways contributing to periodontal changes are scarce. The aim of this study was to evaluate periodontal disease and to investigate its association with endothelial dysfunction and clinical changes in patients with lcSSc.
In 38 lcSSc patients and 38 controls, periodontal status was evaluated by disease-specific questionnaire, dental examination including bleeding on probing (BOP), pocket depth, and plaque index, and dental panoramic radiograph. Periodontopathogen bacteria were collected subgingivally using paper points and interleukin-1 (IL-1) gene polymorphisms were evaluated using buccal swabs. Endothelial dysfunction was measured by flow-mediated dilatation, pulse-wave velocity and biochemical analysis, including arginine metabolites and endothelial microparticles. Additionally, lcSSc-specific clinical changes and parameters were recorded.
Periodontitis was present in 31 patients with lcSSc (81.6%) and in 27 controls (71.1%) (p = .280). LcSSc patients had a lower teeth number (p = .039) and Eikenella corrodens was to a higher degree detectable in patients with lcSSc (p = .041) while the remaining periodontal parameters revealed no differences between both cohorts. Significant correlations between parameters of arterial stiffness, EUSTAR index, number of teeth and BOP were observed (all p < .05). Detection of Prevotella intermedia was associated with selected IL-1 gene polymorphisms (p = .032) and Porphyromonas gingivalis was associated with severe periodontitis (p = .041).
Periodontal disease may occur frequently in patients with lcSSc and may be associated with arterial stiffness and with SSc activity.
局限性皮肤型系统性硬皮病（lcSSc）患者常发生牙周病，但导致牙周变化的潜在途径的数据却很少。本研究旨在评估 lcSSc 患者的牙周病，并探讨其与内皮功能障碍和临床变化的关系。
在 38 例 lcSSc 患者和 38 例对照者中，通过疾病特异性问卷、包括探诊出血（BOP）、牙周袋深度和菌斑指数以及牙科全景片在内的牙科检查来评估牙周状况。使用纸尖采集龈下牙周病原体细菌，并使用颊拭子评估白细胞介素-1（IL-1）基因多态性。通过血流介导的扩张、脉搏波速度和生化分析（包括精氨酸代谢物和内皮微粒）来测量内皮功能障碍。此外，还记录了 lcSSc 特异性的临床变化和参数。
31 例 lcSSc 患者（81.6%）和 27 例对照者（71.1%）存在牙周炎（p=0.280）。lcSSc 患者的牙齿数量较少（p=0.039），且 Eikenella corrodens 在 lcSSc 患者中更易被检测到（p=0.041），而其余牙周参数在两组间无差异。动脉僵硬度、EUSTAR 指数、牙齿数量和 BOP 之间存在显著相关性（均 p<0.05）。检测到中间普氏菌与某些 IL-1 基因多态性相关（p=0.032），而牙龈卟啉单胞菌与严重牙周病相关（p=0.041）。
局限性皮肤型系统性硬皮病患者可能经常发生牙周病，且与动脉僵硬度和 SSc 活动有关。
