Ciurea Andreea, Stanomir Alina, Șurlin Petra, Micu Iulia Cristina, Pamfil Cristina, Leucuța Daniel Corneliu, Rednic Simona, Rasperini Giulio, Soancă Andrada, Țigu Adrian Bogdan, Roman Alexandra, Picoș Andrei, Delean Ada Gabriela
Department of Periodontology, Faculty of Dental Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Emergency County Clinical Hospital Cluj, 400006 Cluj-Napoca, Romania.
Diagnostics (Basel). 2024 Mar 4;14(5):540. doi: 10.3390/diagnostics14050540.
(1) Background: This study aimed to assess the periodontitis burden in systemic sclerosis patients and the possible association between them, and the degree to which some potential risk factors and two potential diagnostic biomarkers may account for this association. (2) Methods: This cross-sectional study included a test group (systemic sclerosis patients) and a control group (non-systemic sclerosis patients). Both groups benefited from medical, periodontal examination and saliva sampling to determine the salivary flow rate and two inflammatory biomarkers (calprotectin, psoriasin). A systemic sclerosis severity scale was established. (3) Results: In the studied groups, comparable periodontitis rates of 88.68% and 85.85%, respectively, were identified. There were no significant differences in the severity of periodontitis among different systemic sclerosis severity, or in the positivity for anti-centromere and anti-SCL70 antibodies. Musculoskeletal lesions were significantly more common in stage III/IV periodontitis ( = 33, 86.84%) than in those in stage I/II ( = 1, 100%, and = 3, 37.5%, respectively) ( = 0.007). Comparable levels of the inflammatory mediators were displayed by the two groups. There were no significant differences in calprotectin and psoriasin levels between diffuse and limited forms of systemic sclerosis. (4) Conclusions: Within the limitations of the current study, no associations between systemic sclerosis and periodontitis, or between their risk factors, could be proven.
(1) 背景：本研究旨在评估系统性硬化症患者的牙周炎负担及其之间可能存在的关联，以及一些潜在风险因素和两种潜在诊断生物标志物对这种关联的影响程度。(2) 方法：这项横断面研究包括一个试验组（系统性硬化症患者）和一个对照组（非系统性硬化症患者）。两组均接受了医学检查、牙周检查和唾液采样，以确定唾液流速和两种炎症生物标志物（钙卫蛋白、牛皮癣素）。建立了系统性硬化症严重程度量表。(3) 结果：在研究组中，分别确定牙周炎发生率相当，为88.68%和85.85%。不同系统性硬化症严重程度之间的牙周炎严重程度，或抗着丝点抗体和抗SCL70抗体的阳性率，均无显著差异。肌肉骨骼病变在III/IV期牙周炎中（n = 33，86.84%）比在I/II期（n = 1，100%，和n = 3，37.5%）明显更常见（p = 0.007）。两组炎症介质水平相当。弥漫型和局限型系统性硬化症之间的钙卫蛋白和牛皮癣素水平无显著差异。(4) 结论：在本研究的局限性范围内，无法证实系统性硬化症与牙周炎之间或其风险因素之间存在关联。
