甲苯达唑的肝毒性。与药物血清浓度的关系。
Hepatotoxicity of mebendazole. Relationship with serum concentrations of the drug.
作者信息
Bekhti A, Pirotte J
机构信息
Secteur de Gastroentérologie, Institut de Médecine, Hôpital de Bavière, Liège, Belgique.
出版信息
Gastroenterol Clin Biol. 1987 Oct;11(10):701-3.
PMID:3692093
Abstract
We report the case of a 47-year-old female patient, suffering from multiple hydatid cysts of the liver, in whom hepatitis developed after mebendazole treatment. Clinical manifestations of hypersensitivity were absent. A correlation was found between serum mebendazole concentrations and the degree of cytolysis; this is compatible with a direct hepatotoxic effect of mebendazole.
摘要
我们报告了一例47岁女性患者的病例，该患者患有肝脏多发棘球蚴囊肿，在接受甲苯咪唑治疗后发生了肝炎。患者无超敏反应的临床表现。发现血清甲苯咪唑浓度与细胞溶解程度之间存在相关性；这与甲苯咪唑的直接肝毒性作用相符。
Zotero 插件