西咪替丁可提高血清甲苯达唑浓度。对肝包虫囊肿治疗的意义。
Cimetidine increases serum mebendazole concentrations. Implications for treatment of hepatic hydatid cysts.
作者信息
Bekhti A, Pirotte J
机构信息
Institut de Médecine, Université de Liège, Hôpital de Bavière, Belgium.
出版信息
Br J Clin Pharmacol. 1987 Sep;24(3):390-2. doi: 10.1111/j.1365-2125.1987.tb03186.x.
In eight patients (five with peptic ulcer disease and three with hydatid cysts), the [14C]-aminopyrine breath test (ABT) and maximum serum concentration of mebendazole following a dose of 1.5 g of mebendazole three times daily were determined before and after treatment with cimetidine (400 mg three times daily for 30 days). Serum mebendazole concentrations were measured in blood samples taken 2 h after each drug intake. Cimetidine lowered the 14CO2 specific activity (SA) at 1 h (P less than 0.01) and increased the maximum serum concentration of mebendazole (P less than 0.01). A significant correlation was found between SA at 1 h and the highest concentration of mebendazole before (r = -0.71, P less than 0.05) and after (r = -0.82, P less than 0.05) cimetidine ingestion. Combined administration of cimetidine and mebendazole resulted in the complete resolution of previously unresponsive hydatid cysts.
在8例患者（5例患有消化性溃疡病，3例患有包虫囊肿）中，在西咪替丁（每日3次，每次400mg，共30天）治疗前后，测定了[14C] - 氨基比林呼气试验（ABT）以及每日3次服用1.5g甲苯咪唑后的甲苯咪唑最大血清浓度。在每次服药后2小时采集的血样中测量血清甲苯咪唑浓度。西咪替丁降低了1小时时的14CO2比活性（SA）（P<0.01），并提高了甲苯咪唑的最大血清浓度（P<0.01）。在服用西咪替丁之前（r = -0.71，P<0.05）和之后（r = -0.82，P<0.05），1小时时的SA与甲苯咪唑的最高浓度之间存在显著相关性。西咪替丁和甲苯咪唑联合给药导致先前无反应的包虫囊肿完全消退。
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