Medical University of Vienna, Center for Physiology and Pharmacology, Schwarzspanierstrasse 17, A-1090 Vienna, Austria.
Medical University of Vienna, Center for Physiology and Pharmacology, Schwarzspanierstrasse 17, A-1090 Vienna, Austria.
Drug Discov Today. 2023 May;28(5):103554. doi: 10.1016/j.drudis.2023.103554. Epub 2023 Mar 13.
Cell migration is a key physiological process in the development and homeostasis of multicellular organisms; errors in this complex system can trigger the development of cancer or inflammatory disorders. Therefore, modulating cell migration provides opportunities for drug discovery. Peptides are gaining importance on the global therapeutics market, given their unique properties compared with established small-molecule drugs or biologics. In this review, we identified over 470 peptides modulating cell migration and analyzed their characteristics. Over 95% of these peptides are in the discovery or preclinical stage, because the transition of peptide hits into drug leads often results in a bottleneck in the development process. We summarize chemical strategies in (pre-)clinical development to enhance drug-like properties of bioactive peptides.
细胞迁移是多细胞生物发育和稳态的关键生理过程；这个复杂系统中的错误会引发癌症或炎症性疾病的发展。因此，调节细胞迁移为药物发现提供了机会。与已确立的小分子药物或生物药物相比，肽类因其独特的性质在全球治疗市场中变得越来越重要。在这篇综述中，我们鉴定了超过 470 种调节细胞迁移的肽，并分析了它们的特性。这些肽中有超过 95%处于发现或临床前阶段，因为肽类命中物向药物先导物的转化常常导致开发过程中的瓶颈。我们总结了（临床前）开发中增强生物活性肽类药物特性的化学策略。
