Yang Qimeng, Hu Zhipeng, Jiang Hongyu, Wang Jialing, Han Han, Shi Wei, Qian Hai
Centre of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Centre of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Chin J Nat Med. 2025 Jan;23(1):31-42. doi: 10.1016/S1875-5364(25)60800-4.
Peptide-based therapies have attracted considerable interest in the treatment of cancer, diabetes, bacterial infections, and neurodegenerative diseases due to their promising therapeutic properties and enhanced safety profiles. This review provides a comprehensive overview of the major trends in peptide drug discovery and development, emphasizing preclinical strategies aimed at improving peptide stability, specificity, and pharmacokinetic properties. It assesses the current applications and challenges of peptide-based drugs in these diseases, illustrating the pharmaceutical areas where peptide-based drugs demonstrate significant potential. Furthermore, this review analyzes the obstacles that must be overcome in the future, aiming to provide valuable insights and references for the continued advancement of peptide-based drugs.
基于肽的疗法因其具有前景的治疗特性和更高的安全性，在癌症、糖尿病、细菌感染和神经退行性疾病的治疗中引起了相当大的关注。本综述全面概述了肽类药物发现和开发的主要趋势，强调了旨在改善肽稳定性、特异性和药代动力学特性的临床前策略。它评估了基于肽的药物在这些疾病中的当前应用和挑战，阐明了基于肽的药物显示出巨大潜力的制药领域。此外，本综述分析了未来必须克服的障碍，旨在为基于肽的药物的持续发展提供有价值的见解和参考。
