Health Services Management Department, Guizhou Medical University, Gui'an, China; College of Pharmacy, Jinan University, Guangzhou, China.
College of Pharmacy, Jinan University, Guangzhou, China.
Value Health. 2023 Jul;26(7):968-973. doi: 10.1016/j.jval.2023.03.003. Epub 2023 Mar 13.
The published international EQ-5D-Y-3L valuation protocol does not recommend the composite time trade-off (cTTO) method as the primary valuation method because of 2 major concerns. First, the cTTO method was shown to generate high values. Second, the cTTO method is not as feasible for valuing children's health as other established methods. This study aimed to explore the feasibility of using cTTO values alone to estimate EQ-5D-Y-3L value sets.
We analyzed the cTTO data derived from the recently completed Chinese EQ-5D-Y-3L valuation study in which a total of 28 health states were valued. We assessed the feasibility of the cTTO tasks in terms of survey completion time and participant-reported difficulty of understanding the task, differentiating the health states, and deciding the answer. We also examined the data distribution characteristics and modeled the data using different models.
In total, 418 participants completed the cTTO interview. On average, participants took approximately 35.70 minutes (SD 12.42) to complete the interview and made 13.21 moves (SD 9.00) in the cTTO tasks. There were 74.16%, 59.33%, and 11.48% of participants indicated that it was easy to understand the cTTO tasks, easy to differentiate between the health states, and difficult to decide on an indifference point, respectively. The data distribution was smooth, and a random-effects model performed the best in terms of coefficient significance, monotonicity, and predictive accuracy.
Our finding suggests that estimating EQ-5D-Y-3L value sets using cTTO data alone is feasible and therefore could be considered as an option in future valuation studies for EQ-5D-Y-3L.
已发表的国际 EQ-5D-Y-3L 价值评估协议不推荐综合时间权衡（cTTO）方法作为主要的评估方法，原因有两点。首先，cTTO 方法生成的数值较高。其次，cTTO 方法对于评估儿童健康状况不如其他既定方法可行。本研究旨在探索单独使用 cTTO 值来估计 EQ-5D-Y-3L 值集的可行性。
我们分析了最近完成的中国 EQ-5D-Y-3L 价值评估研究中得出的 cTTO 数据，其中总共评估了 28 种健康状况。我们根据调查完成时间和参与者报告的理解任务、区分健康状况和决定答案的难度，评估 cTTO 任务的可行性。我们还检查了数据分布特征，并使用不同的模型对数据进行建模。
共有 418 名参与者完成了 cTTO 访谈。平均而言，参与者完成访谈大约需要 35.70 分钟（SD 12.42），并在 cTTO 任务中做出 13.21 次移动（SD 9.00）。分别有 74.16%、59.33%和 11.48%的参与者表示理解 cTTO 任务容易、区分健康状况容易和难以确定中立点。数据分布平滑，随机效应模型在系数显著性、单调性和预测准确性方面表现最佳。
我们的研究结果表明，仅使用 cTTO 数据估计 EQ-5D-Y-3L 值集是可行的，因此可以考虑在未来的 EQ-5D-Y-3L 价值评估研究中作为一种选择。
