Wu Y J, Zhang W S, Zhu F, Zhu T, Jin Y L, Pan J, Jiang C Q
Department of Molecular Epidemiology, Guangzhou Twelfth People's Hospital,Guangzhou 510620,China School of Public Health,Guangzhou Medical University,Guangzhou 511436,China.
Department of Molecular Epidemiology, Guangzhou Twelfth People's Hospital,Guangzhou 510620,China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2023 Mar 6;57(3):433-437. doi: 10.3760/cma.j.cn112150-20220601-00560.
To explore the relationship between the early or delayed age at natural menopause and metabolic syndrome (MS) in women. A total of 4 734 natural menopausal women who completed the baseline survey from November 2017 to January 2020 in the Guangzhou Middle-aged and Elderly Chronic Disease Prospective Cohort Study were selected in this cross-sectional study. Data on general demographic characteristics, disease history and female physiological health indicators were collected. Logistic regression model and restricted cubic spline curve were used to analyze the relationship between the age at natural menopause and MS. The results showed that the mean age of the subjects was (60±6) years old. The (,) age at natural menopause was 50 (49, 52) years old, and the prevalence of MS was 14.8%(699/4 734). After adjusting for confounders, the age at natural menopause was closely related to MS in an approximate"U"shape. Compared with the group of normal age at natural menopause, the early age at menopause (=1.52, 95%: 1.12-2.06) and delayed age at menopause (=1.77, 95%: 1.36-2.30) had a higher risk of MS. In the group with time since menopause ≤6 years and 7-9 years, the risk of MS in the group with delayed age at menopause was 2.40 times (95%: 1.54-3.75) and 2.19 times (95%: 1.11-4.31) higher than that in the group with normal menopausal age, respectively. In conclusion, the early and delayed age at natural menopause increased the risk of MS. The increased risk of MS in delayed age at natural menopause mainly occurred within 10 years since menopause.
探讨女性自然绝经年龄早或晚与代谢综合征（MS）之间的关系。在这项横断面研究中，选取了2017年11月至2020年1月在广州中老年慢性病前瞻性队列研究中完成基线调查的4734名自然绝经女性。收集了一般人口统计学特征、疾病史和女性生理健康指标的数据。采用逻辑回归模型和受限立方样条曲线分析自然绝经年龄与MS之间的关系。结果显示，受试者的平均年龄为（60±6）岁。自然绝经年龄为50（49，52）岁，MS患病率为14.8%（699/4734）。调整混杂因素后，自然绝经年龄与MS呈近似“U”形密切相关。与自然绝经年龄正常组相比，绝经年龄早（=1.52，95%：1.12 - 2.06）和绝经年龄晚（=1.77，95%：1.36 - 2.30）患MS的风险更高。在绝经后时间≤6年和7 - 9年的组中，绝经年龄晚组患MS的风险分别比绝经年龄正常组高2.40倍（95%：1.54 - 3.75）和2.19倍（95%：1.11 - 4.31）。综上所述，自然绝经年龄早和晚均增加了患MS的风险。自然绝经年龄晚增加患MS的风险主要发生在绝经后10年内。
