Haug Elisabeth, Øie Merete G, Svendsen Ingrid H, Møller Paul, Nelson Barnaby, Melle Ingrid
Department of Acute Psychiatry and Psychosis Treatment, Innlandet Hospital Trust, Brumunddal, Norway.
Department of Research, Innlandet Hospital Trust, Brumunddal, Norway.
Front Psychol. 2023 Feb 27;14:1124859. doi: 10.3389/fpsyg.2023.1124859. eCollection 2023.
Basic self-disorders (SDs) and neurocognitive impairments are fundamental trait-like aspects of schizophrenia spectrum disorders. There has been little research on the association between SDs and neurocognitive impairments in schizophrenia, and no longitudinal studies have investigated if they are related. The aim of this study was to investigate the association between SDs and neurocognitive function in a follow-up study of patients with schizophrenia.
SDs and neurocognition were examined in 35 patients with schizophrenia during their first treatment and 7 years later (mean 7.1, SD 0.42). SDs were examined with the Examination of Anomalous Self-Experience (EASE) instrument. The neurocognitive examination included assessments of psychomotor speed, executive- and memory functions.
Poorer executive functions at baseline were significantly associated with more SDs 7 years later and smaller reductions in SDs over time. There were no significant associations between other neurocognitive functions and SDs.
Executive functions are important for self-regulation, and impairments in these functions in everyday life may have an impact on the development and/or persistence of SDs.
基本自我障碍（SDs）和神经认知障碍是精神分裂症谱系障碍的基本特质样方面。关于精神分裂症中SDs与神经认知障碍之间的关联研究较少，且尚无纵向研究探讨它们是否相关。本研究的目的是在一项对精神分裂症患者的随访研究中，调查SDs与神经认知功能之间的关联。
对35例精神分裂症患者在首次治疗时及7年后（平均7.1年，标准差0.42）进行SDs和神经认知检查。使用异常自我体验检查（EASE）工具检查SDs。神经认知检查包括对精神运动速度、执行功能和记忆功能的评估。
基线时较差的执行功能与7年后更多的SDs显著相关，且随着时间推移SDs的减少幅度较小。其他神经认知功能与SDs之间无显著关联。
执行功能对自我调节很重要，日常生活中这些功能的损害可能会对SDs的发展和/或持续存在产生影响。
