Heynen M J, Zaman Z, Verwilghen R L
Department of Medical Research, University of Leuven, Belgium.
Haematologia (Budap). 1987;20(3):131-53.
Effect of 17 hr intoxication of lead on the different maturation stages of erythroid cells were studied in rat. Morphometric methods were used to analyse the lead-induced ultrastructural changes in the early, intermediate, late erythroblasts and reticulocytes. It was found that the toxic effect of lead increases with maturation. Energy-dispersive Röntgen micro-analysis showed that fibrillar structures within vesicles and endoplasmic reticulum contained lead.
研究了大鼠经17小时铅中毒对红系细胞不同成熟阶段的影响。采用形态计量学方法分析铅诱导的早幼红细胞、中幼红细胞、晚幼红细胞和网织红细胞的超微结构变化。结果发现，铅的毒性作用随着细胞成熟而增强。能量色散X射线微分析表明，囊泡和内质网内的纤维状结构含有铅。
