Unal Ali, Bayram Basak, Ergan Begum, Can Kazim, Ergun Yagiz Kagan, Kilinc Oguz
Dept of Emergency Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey.
Dept of Pulmonary and Critical Care, Dokuz Eylul University School of Medicine, Izmir, Turkey.
ERJ Open Res. 2023 Mar 13;9(2). doi: 10.1183/23120541.00436-2022. eCollection 2023 Mar.
While clinical decision rules have been developed to evaluate exacerbations and decisions on hospitalisation and discharge in emergency departments (EDs) in patients with chronic obstructive pulmonary disease (COPD), these rules are not widely used in EDs. In this study, we compare the predictive efficacy of the Ottawa Chronic Obstructive Pulmonary Disease Risk Scale (OCRS) and the Dyspnea, Eosinopenia, Consolidation, Acidemia, and Atrial Fibrillation (DECAF) score in estimating the short-term poor outcome of patients in our ED with exacerbations of COPD.
This single-centre prospective observational study was conducted over 6 months. Patients with acute exacerbations of COPD admitted to the ED during the study period were included in the study. A poor outcome was defined as any of the following: readmission and requiring hospitalisation within 14 days of discharge, requiring mechanical ventilation on the first admission, hospitalisation for longer than 14 days on the first admission, or death within 30 days. The sensitivity and specificity of the OCRS and the DECAF score for a poor outcome and for mortality were calculated.
Of the 385 patients who participated in the study, 85 were excluded based on the exclusion criteria. 66% of the patients were male, and the mean age was 70.15±10.36 years. A total of 20.7% of all patients (n=62) experienced poor outcomes. The sensitivity of an OCRS score <1 for predicting a poor outcome in patients was 96.8% (95% CI 88.8-99.6%) and the specificity was 18.5% (95% CI 13.8-24.0%). The sensitivity and specificity of an OCRS score <2 were 83.3% (95% CI 35.9-99.6%) and 65.5% (95% CI 59.6-70.7%), respectively. The sensitivity and specificity of a DECAF score <1 were 88.7% (95% CI 78.1-95.3%) and 34.5% (95% CI 28.4-40.9%), respectively. When the DECAF score was <2, sensitivity and specificity were 69.3% (95% CI 56.4-80.4%) and 74.8% (95% CI 68.8-80.2%), respectively.
Our physicians achieved high specificity but low sensitivity in predicting a poor outcome. The OCRS is the more sensitive of the two tools, while the DECAF score is more specific in predicting a poor outcome when all threshold values are evaluated. While both tools may results in unnecessary hospitalisation, they can reduce the incidence of hospital discharge of patients with exacerbations of COPD who will develop poor outcomes in the ED.
虽然已经制定了临床决策规则来评估慢性阻塞性肺疾病(COPD)患者在急诊科(ED)的病情加重情况以及住院和出院决策,但这些规则在急诊科并未得到广泛应用。在本研究中,我们比较了渥太华慢性阻塞性肺疾病风险量表(OCRS)和呼吸困难、嗜酸性粒细胞减少、实变、酸血症和心房颤动(DECAF)评分在预测我们急诊科中COPD加重患者短期不良结局方面的预测效能。
本单中心前瞻性观察性研究持续了6个月。研究期间入住急诊科的COPD急性加重患者被纳入研究。不良结局定义为以下任何一种情况:出院后14天内再次入院并需要住院治疗、首次入院时需要机械通气、首次入院住院时间超过14天或30天内死亡。计算了OCRS和DECAF评分对不良结局和死亡率的敏感性和特异性。
参与研究的385例患者中,85例根据排除标准被排除。66%的患者为男性,平均年龄为70.15±10.36岁。所有患者中共有20.7%(n = 62)经历了不良结局。OCRS评分<1预测患者不良结局的敏感性为96.8%(95%CI 88.8 - 99.6%),特异性为18.5%(95%CI 13.8 - 24.0%)。OCRS评分<2的敏感性和特异性分别为83.3%(95%CI 35.9 - 99.6%)和65.5%(95%CI 59.6 - 70.7%)。DECAF评分<1的敏感性和特异性分别为88.7%(95%CI 78.1 - 95.3%)和34.5%(95%CI