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接受免疫抑制治疗的肝移植患者的疾病认知水平对其合理用药水平的影响。

The effect of illness perception levels of liver transplant patients receiving immunosuppressive therapy on their rational drug use levels.

作者信息

Mert Kartal, Nese Karakas, Gürkan Kapikiran

机构信息

Health Sciences Faculty, Malatya Turgut Ozal University, Malatya, Turkey.

Faculty of Medicine, Malatya Turgut Ozal University, Malatya, Turkey.

出版信息

Heliyon. 2023 Feb 28;9(3):e14033. doi: 10.1016/j.heliyon.2023.e14033. eCollection 2023 Mar.

Abstract

OBJECTIVE

Since 50% of drug use all over the world is used other than rational drug use, rational drug use, which is associated with the perception of the disease, is important for the course of the disease. This study aimed to determine the effect of disease perception levels on rational drug use in liver transplant patients receiving immunosuppressive therapy.

METHODS

This descriptive and cross-sectional study was conducted with patients who came to the outpatient clinic for control between May-September 2022 with the participation of patients who underwent liver transplantation and followed up in a liver transplant institute in eastern Turkey. In the collection of the study data, "sociodemographic information form" prepared by the researchers, "Brief Illness Perception Questionnaire", and "Rational Drug Use Scale" were employed.

RESULTS

In this study conducted with 206 patients, the mean age of patients with liver transplantation was 48.66 ± 9.4 years, 59.7% were male, 80.1% were married, and 33.5% were high school graduates. It was determined that the disease perception levels and rational drug use levels of the patients who underwent liver transplantation were moderate. It was also determined that as the education levels of the liver transplant patients increased, their levels of illness perception and rational drug use also statistically significantly increased (p < 0.05). It was found that there was a significant and moderate relationship between illness perception and rational drug use, and that as their level of illness perception increased, their level of rational drug use also increased (r:0.622, p < 0.05). It was observed that the disease perception level explained 38.7% of the change in rational drug use (R:387, p < 0.05).

CONCLUSIONS

In the study, it was observed that high illness perception levels of liver transplant patients increased their levels of rational drug use. It is important to raise the awareness of patients in order for them to cope with illnesses and to have a high level of illness perception.

摘要

目的

由于全球50%的药物使用并非合理用药,而合理用药与疾病认知相关,对疾病进程至关重要。本研究旨在确定疾病认知水平对接受免疫抑制治疗的肝移植患者合理用药的影响。

方法

本描述性横断面研究于2022年5月至9月在土耳其东部一家肝移植研究所就诊并接受随访的肝移植患者参与下,对前来门诊进行复查的患者进行。在收集研究数据时,采用了研究人员编制的“社会人口学信息表”、“简短疾病认知问卷”和“合理用药量表”。

结果

本研究共纳入206例患者,肝移植患者的平均年龄为48.66±9.4岁,男性占59.7%,已婚者占80.1%,高中毕业生占33.5%。结果显示,肝移植患者的疾病认知水平和合理用药水平中等。还发现,随着肝移植患者教育水平的提高,他们的疾病认知水平和合理用药水平在统计学上也显著提高(p<0.05)。发现疾病认知与合理用药之间存在显著的中等程度关系,随着疾病认知水平的提高,合理用药水平也随之提高(r:0.622,p<0.05)。观察到疾病认知水平解释了合理用药变化的38.7%(R:0.387,p<0.05)。

结论

在本研究中,观察到肝移植患者较高的疾病认知水平提高了他们的合理用药水平。提高患者的意识对于他们应对疾病并拥有较高的疾病认知水平很重要。

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Biomarkers of immune tolerance in liver transplantation.肝移植中免疫耐受的生物标志物
Hum Immunol. 2018 May;79(5):388-394. doi: 10.1016/j.humimm.2018.02.010. Epub 2018 Feb 17.
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The brief illness perception questionnaire.简短疾病感知问卷。
J Psychosom Res. 2006 Jun;60(6):631-7. doi: 10.1016/j.jpsychores.2005.10.020.

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