Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076, India.
Department of Interdisciplinary Program in Climate Studies, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
Chem Soc Rev. 2023 Apr 3;52(7):2391-2479. doi: 10.1039/d0cs01466d.
The term "C-H functionalisation" incorporates C-H activation followed by its transformation. In a single line, this can be defined as the conversion of carbon-hydrogen bonds into carbon-carbon or carbon-heteroatom bonds. The catalytic functionalisation of C-H bonds using transition metals has emerged as an atom-economical technique to engender new bonds without activated precursors which can be considered as a major drawback while attempting large-scale synthesis. Replacing the transition-metal-catalysed approach with a metal-free strategy significantly offers an alternative route that is not only inexpensive but also environmentally benign to functionalize C-H bonds. Recently metal free synthetic approaches have been flourishing to functionalize C-H bonds, motivated by the search for greener, cost-effective, and non-toxic catalysts. In this review, we will highlight the comprehensive and up-to-date discussion on recent examples of ground-breaking research on green and sustainable metal-free C-H bond functionalisation.
“C-H 官能化”一词包含 C-H 键的活化及其转化。简而言之，这可以定义为将碳氢键转化为碳碳键或碳杂原子键。使用过渡金属催化 C-H 键官能化已成为一种原子经济性技术，可在不使用活化前体的情况下生成新键，而在尝试大规模合成时，这可能是一个主要缺点。用无金属策略取代过渡金属催化方法，为官能化 C-H 键提供了一条不仅廉价而且对环境友好的替代途径。最近，无金属合成方法在寻找更绿色、更经济高效、无毒催化剂的推动下，蓬勃发展，以实现 C-H 键的官能化。在这篇综述中，我们将重点介绍关于绿色可持续无金属 C-H 键官能化的开创性研究的最新实例的全面和最新讨论。
