在HO/HFIP中，吩恶嗪与磺酰肼的无催化剂区域选择性磺酰化反应
Catalyst-free regioselective sulfonylation of phenoxazine with sulfonyl hydrazides in HO/HFIP.
作者信息
Li Yanan, Li Lin, Tan Jing, Yang Chenpei, Wang Yifei, Li Feiyang, Liu Chenyu, Wu Xiaohui, Sun Jianan
机构信息
School of Chemical and Blasting Engineering, Anhui Province Key Laboratory of Specialty Polymers, Anhui University of Science and Technology Huainan 232001 China
School of Biomedical Engineering, School of Health Management, Anhui Medical University Hefei 230032 China
出版信息
RSC Adv. 2024 Oct 3;14(43):31429-31432. doi: 10.1039/d4ra06625a. eCollection 2024 Oct 1.
A facile catalyst-free sulfonylation of phenoxazine with sulfonyl hydrazides was efficiently developed in HO/HFIP without any catalyst. This metal- and catalyst-free protocol is suitable for aromatic and aliphatic reagents to afford the corresponding sulfones in moderate to high yields. A gram-scale experiment was performed to assess the practicability of the method.
在无任何催化剂的情况下，吩噁嗪与磺酰肼在HO/HFIP中高效地实现了简便的无催化剂磺酰化反应。这种无金属和无催化剂的方法适用于芳香族和脂肪族试剂，能以中等到高的产率得到相应的砜。进行了克级实验以评估该方法的实用性。
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