Department of Chemical Engineering and Food Science, Hubei University of Arts and Science, 296 Longzhong Road, Xiangyang, 441053, P. R. China.
State Key Laboratory of Advanced Technology for, Materials Synthesis and Processing, Wuhan University of Technology, 122 Luoshi Road, Wuhan, 430070, P. R. China.
Chem Rec. 2023 May;23(5):e202300020. doi: 10.1002/tcr.202300020. Epub 2023 Mar 30.
Carbon-heteroatom bond formation under transition-metal free conditions provides a powerful synthetic alternative for the efficient synthesis of valuable molecules. In particular, C-N and C-O bonds are two important types of carbon-heteroatom bonds. Thus, continuous efforts have been deployed to develop novel C-N/C-O bond formation methodologies involving various catalysts or promoters under TM-free conditions, which enables the synthesis of various functional molecules comprising C-N/C-O bonds in a facile and sustainable manner. Considering the significance of C-N/C-O bond construction in organic synthesis and materials science, this review aims to comprehensively present selected examples on the construction of C-N (including amination and amidation) and C-O (including etherification and hydroxylation) bonds without transition metals. Besides, the involved promoters/catalysts, substrate scope, potential application and possible reaction mechanisms are also systematically discussed.
在无过渡金属条件下形成碳-杂原子键为高效合成有价值的分子提供了一种强大的合成替代方法。特别是，C-N 和 C-O 键是两种重要的碳-杂原子键。因此，人们一直在努力开发新型的 C-N/C-O 键形成方法，涉及各种催化剂或促进剂在无 TM 条件下，能够以简单可持续的方式合成各种包含 C-N/C-O 键的功能分子。考虑到 C-N/C-O 键在有机合成和材料科学中的重要性，本综述旨在全面介绍在无过渡金属条件下构建 C-N（包括氨化和酰胺化）和 C-O（包括醚化和羟化）键的选定实例。此外，还系统地讨论了所涉及的促进剂/催化剂、底物范围、潜在应用和可能的反应机制。
