Pakpahan Cennikon, Ilhamsyah Ilhamsyah, Supardi Supardi, Narulita Pety, Agustinus Agustinus, Darmadi Darmadi
Andrology Study Program, Faculty of Medicine, Universitas Airlangga, Surabaya; Department of Biomedical Sciences, Faculty of Medicine, Universitas Airlangga, Surabaya; Andrology Outpatient Clinic, General Academic Dr. Soetomo Hospital, Surabaya.
Andrology Study Program, Faculty of Medicine, Universitas Airlangga, Surabaya; Andrology Outpatient Clinic, General Academic Dr. Soetomo Hospital, Surabaya.
Arch Ital Urol Androl. 2023 Mar 15;95(1):11162. doi: 10.4081/aiua.2023.11162.
This study aims to investigate the relationship between Neutrophil- Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR) with Erectile Dysfunction (ED) and Peyronie's disease (PD).
We conducted a meta-analysis of the observational study by searching for the appropriate keywords in eight databases. The risk of publication bias of the included studies was assessed by Egger's test and Kendall's t. The data extraction was carried out for each study and analysed using Revman 5.0.
There were eleven eligible studies out of the 411 studies retrieved. Eight studies were conducted on cases of erectile dysfunction, and three studies on Peyronie's disease. There was a significant relationship between NLR, PLR and ED (SMD: 0.59, 95% CI: 0.33-0.85 and SMD: 0.64, 95% CI: 0.13-1.16, respectively). The same was also found for PD. The active phase of PD tended to have higher NLR (SMD: 0.68, 95% CI: 0.43-0.92) and PLR (SMD: 0.27, 95% CI: 0.06-0.49) compared to the chronic phase. No publication bias was found in both ED and PD studies.
NLR and PLR indicate an ongoing inflammatory process in both ED and PD. These findings can be used as markers of treatment and prognosis of both diseases in sexual health care.
本研究旨在探讨中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）与勃起功能障碍（ED）和佩罗尼氏病（PD）之间的关系。
我们通过在八个数据库中搜索适当的关键词，对观察性研究进行了荟萃分析。采用Egger检验和Kendall's t评估纳入研究的发表偏倚风险。对每项研究进行数据提取，并使用Revman 5.0进行分析。
在检索到的411项研究中，有11项符合条件。8项研究针对勃起功能障碍病例，3项研究针对佩罗尼氏病。NLR、PLR与ED之间存在显著关系（标准化均数差分别为：0.59，95%可信区间：0.33 - 0.85和0.64，95%可信区间：0.13 - 1.16）。PD的情况也是如此。与慢性期相比，PD的急性期NLR（标准化均数差：0.68，95%可信区间：0.43 - 0.92）和PLR（标准化均数差：0.27，95%可信区间：0.06 - 0.49）往往更高。在ED和PD研究中均未发现发表偏倚。
NLR和PLR表明ED和PD中存在持续的炎症过程。这些发现可作为性健康保健中这两种疾病治疗和预后的标志物。
