Aschauer Judith, Sima Michaela, Imhof Martin
Karl Landsteiner Society, Institute for Cell-focused Therapy, Korneuburg; Medical University of Vienna, Vienna.
Karl Landsteiner Society, Institute for Cell-focused Therapy, Korneuburg.
Arch Ital Urol Androl. 2023 Mar 13;95(1):11157. doi: 10.4081/aiua.2023.11157.
This study aims to evaluate the safety and efficacy of a standard micronutrient preparation to improve semen parameters and seminal oxidative stress in adult male subjects after Coronavirus Disease 2019 (COVID-19) disease.
For this prospective pilot study, 30 males aged 20-50 years who had recently recovered from a symptomatic SARS-CoV-2 infection were recruited from June to October 2021 through a public call for participation. Participants of the study group (n = 30) received two semen analyses according to WHO criteria at an interval of 12 weeks, during which they daily received a micronutrient preparation (L-carnitine, L-arginine, coenzyme Q10, vitamin E, zinc, folic acid, glutathione and selenium). Changes in major semen variables and seminal oxidative stress levels before and after therapy were analyzed and compared to a control group (n = 10) adhering to the same inclusion criteria, including subjects who recently recovered from symptomatic COVID-19 disease without micronutrient supplementation within the 12 weeks between the two semen analyses.
After 3 months of micronutrient supplementation the rate of normal semen analysis results in the study group increased significantly (p = 0.009) by 66.7%: from 50.0% before to 83.3% after therapy. There was a significant increase in progressive (p = 0.014) and overall motility (p = 0.05) as well as in the vitality (p = 0.0004) of semen cells after 12 weeks of micronutrient intake. In the control group there were no significant changes in any semen parameter or in the rate of normal semen analysis results over the 3-month observation period. In both groups, sperm density, morphology and oxidative stress did not improve significantly.
Our data suggests that supplementation of certain micronutrients may be a safe way to support recovery of impaired semen parameters in male adults recovered from COVID-19 disease.
本研究旨在评估一种标准微量营养素制剂对改善2019冠状病毒病（COVID-19）康复后成年男性受试者精液参数和精液氧化应激的安全性和有效性。
在这项前瞻性试点研究中，2021年6月至10月通过公开招募，纳入了30名年龄在20至50岁之间、近期从有症状的严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）感染中康复的男性。研究组（n = 30）的参与者按照世界卫生组织标准，每隔12周接受两次精液分析，在此期间他们每天服用一种微量营养素制剂（左旋肉碱、左旋精氨酸、辅酶Q10、维生素E、锌、叶酸、谷胱甘肽和硒）。分析并比较治疗前后主要精液变量和精液氧化应激水平的变化，并与遵循相同纳入标准的对照组（n = 10）进行比较，对照组包括在两次精液分析之间的12周内未补充微量营养素、近期从有症状的COVID-19疾病中康复的受试者。
补充微量营养素3个月后，研究组精液分析结果正常的比例显著增加（p = 0.009），增加了66.7%：从治疗前的50.0%增至治疗后的83.3%。摄入微量营养素12周后，精液细胞的前向运动率（p = 0.014）、总运动率（p = 0.05）以及活力（p = 0.0004）均显著增加。在对照组中，在3个月的观察期内，任何精液参数或精液分析结果正常的比例均无显著变化。在两组中，精子密度、形态和氧化应激均未显著改善。
我们的数据表明，补充某些微量营养素可能是支持从COVID-19疾病康复的成年男性受损精液参数恢复的一种安全方法。
