Ogurtsov R P
Zh Mikrobiol Epidemiol Immunobiol. 1979 Feb(2):65-9.
The immunization of rabbits with the cells and the disintegration products of fractions of the cytoplasmic membranes of group A streptococcus (type 1) in incomplete Freund adjuvant, introduced in a single injection into the pads of the paws, caused lesions in autoplastic skin grafts and accelerated the rejection of alloplastic skin grafts. The rabbits showed positive delayed-type skin reactions to streptococcus and homologous skin antigens, and lymphocytes specifically reacting with FITC-labeled homologous skin antigen were found in their blood. Prolonged intravenous immunization with streptococcus, which induced the formation of complement fixing antibodies to homologous skin antigens, did not influence the taking of autoplastic and alloplastic skin grafts. The injection of hyperimmune streptococcus rabbit antiserum containing antibodies to skin antigens to intact rabbits produced no lesions in the autoplastic skin grafts and prolonged the lift of the alloplastic skin grafts.
用A组1型链球菌细胞质膜各组分的细胞及崩解产物，在不完全弗氏佐剂中对兔进行免疫，单次注射到爪垫中，可引起自身皮肤移植片出现病变，并加速异体皮肤移植片的排斥。这些兔对链球菌和同源皮肤抗原有阳性迟发型皮肤反应，且在其血液中发现了与异硫氰酸荧光素标记的同源皮肤抗原特异性反应的淋巴细胞。用链球菌进行长时间静脉免疫，可诱导产生针对同源皮肤抗原的补体结合抗体，但这并不影响自身和异体皮肤移植片的存活。向未免疫的兔注射含有皮肤抗原抗体的超免疫链球菌兔抗血清，自身皮肤移植片未出现病变，异体皮肤移植片的存活时间延长。
