Ogurtsov R P
Zh Mikrobiol Epidemiol Immunobiol. 1978 Apr(4):62-7.
In combined administration of cyclophosphamide and lymphocytes of mice (CC57BR XX C3H) F1 to mice CC57BR there was observed a tolerance to alloantigens of mice C3H. Immunization of the tolerant mice with the vaccines of streptococcus, group A, and Candida albicans, containing antigens similar to the transplantation ones, led, to the partial destruction of the tolerance. This was expressed in the reduction in the CC57BR mice of the survival of skin allotransplants of mice C3H and the appearance in the lymphoid organs of lymphocytes with the cytotoxic activity against the allogenic target cells. In case of the tolerance destruction the amount of the recipient's lymphocytes forming rosettes with the erythrocytes of mice C3H remained unchanged, but the stem cell count fell in the spleen and the lymph nodes. The total amount of the T- and B-lymphocytes in the lymphoid organs was unchanged in destruction of the tolerance.
在将环磷酰胺与（CC57BR×C3H）F1小鼠的淋巴细胞联合给予CC57BR小鼠的过程中，观察到对C3H小鼠同种异体抗原的耐受性。用含有与移植抗原相似抗原的A组链球菌疫苗和白色念珠菌疫苗对耐受小鼠进行免疫，导致耐受性部分破坏。这表现为CC57BR小鼠中C3H小鼠皮肤同种异体移植存活率降低，以及在淋巴器官中出现对同种异体靶细胞具有细胞毒性活性的淋巴细胞。在耐受性破坏的情况下，与C3H小鼠红细胞形成玫瑰花结的受体淋巴细胞数量保持不变，但脾脏和淋巴结中的干细胞数量减少。在耐受性破坏时，淋巴器官中T淋巴细胞和B淋巴细胞的总数不变。
