[Use of cross-reacting microbial antigens reversal of tolerance acquired for mouse transplantation antigens].

Immunization of CC57BR mice tolerant to the C. albicans antigens and the affiliated transplantation antigens of C3H mice, with group A streptococcus (type I) containing the antigens cross reacting with the donor tissues, abrogated the tolerance to the C3H mice alloantigens. This was expressed in the shortened survival of the skin allotransplant and in increased rate of elimination from the lymph nodes and the spleen of labeled 51Cr donor lymphoid cells. The immune response to the C. albicans antigens was not restored.