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食管原发性恶性黑色素瘤的治疗与预后

Treatment and prognosis of primary malignant melanoma of the esophagus.

作者信息

Cheng Lei, Guo Zheng-Ying, Lei Lei, Wang Wen-Xian, Xu Chun-Wei, Fang Mei-Yu

机构信息

Department of Thoracic Radiotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, China.

Institute of Cancer and Basic Medicine (ICBM) of Chinese Academy of Sciences, Hangzhou, China.

出版信息

Transl Cancer Res. 2020 Jul;9(7):4141-4147. doi: 10.21037/tcr-19-2349.

DOI:10.21037/tcr-19-2349
PMID:35117783
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8798518/
Abstract

BACKGROUND

Primary malignant melanoma of the esophagus (PMME) is rare with high malignancy and poor prognosis. The aim of this study was to investigate the relationship between prognosis and clinicopathological characteristics of this disease.

METHODS

A total of 9 patients with PMME were treated in Zhejiang Cancer Hospital between 2009 and 2019 retrospectively. According to 8th edition AJCC/UICC staging of cancers of the esophagus and esophagogastric junction, none of the patients were in stage I. However, 5 patients were in stage II, 2 patients were in stage III, and 2 patients were in stage IV at diagnosis. Five patients received surgery, while one of them received palliative resection. Three patients received postoperative chemotherapy; two of them (2/5) were diagnosed with recurrence. One patient in stage II received targeted therapy. One patient in stage III received first line chemotherapy and efficacy evaluation was stable disease (SD). Another one in stage III received biotherapy. One patient in stage IV received Chinese Medicine treatment and another received chemotherapy and palliative surgery.

RESULTS

The 1-year disease-free survival (DFS) and overall survival (OS) rates of stage II who received surgery were 50% (2/4) and 100% (4/4) respectively. The 2-year DFS and OS rates were 50% (2/4) and 75% (3/4), respectively. However, patients with stage III-IV have a very poor prognosis. The 1-year OS is 0%.

CONCLUSIONS

Due to the small sample size, the statistic efficacy is low, but it can provide a certain theoretical basis for future research.

摘要

背景

原发性食管恶性黑色素瘤（PMME）罕见，恶性程度高，预后差。本研究旨在探讨该疾病预后与临床病理特征之间的关系。

方法

回顾性分析2009年至2019年期间在浙江省肿瘤医院接受治疗的9例PMME患者。根据第8版美国癌症联合委员会（AJCC）/国际抗癌联盟（UICC）食管癌和食管胃交界癌分期，所有患者均不在I期。然而，诊断时5例患者为II期，2例为III期，2例为IV期。5例患者接受了手术，其中1例接受了姑息性切除。3例患者接受了术后化疗；其中2例（2/5）被诊断为复发。1例II期患者接受了靶向治疗。1例III期患者接受了一线化疗，疗效评估为疾病稳定（SD）。另1例III期患者接受了生物治疗。1例IV期患者接受了中医治疗，另1例接受了化疗和姑息性手术。

结果

接受手术的II期患者1年无病生存率（DFS）和总生存率（OS）分别为50%（2/4）和100%（4/4）。2年DFS和OS率分别为50%（2/4）和75%（3/4）。然而，III-IV期患者的预后非常差。1年OS为0%。

结论

由于样本量小，统计效能低，但可为未来研究提供一定的理论依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df37/8798518/07a3a6fab654/tcr-09-07-4141-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df37/8798518/439f07c01edb/tcr-09-07-4141-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df37/8798518/07a3a6fab654/tcr-09-07-4141-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df37/8798518/439f07c01edb/tcr-09-07-4141-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df37/8798518/07a3a6fab654/tcr-09-07-4141-f2.jpg

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