Xia Ning, Wang Hao, Chen Yu, Fan Xiao-Jun, Nie Xiu-Hong
Department of Respiratory Diseases, Xuanwu Hospital, Capital Medical University, Beijing, People's Republic of China.
Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Nat Sci Sleep. 2023 Mar 10;15:79-88. doi: 10.2147/NSS.S396893. eCollection 2023.
We aimed to explore the relationship of sleep efficiency (SE) with the prevalence of hypertension in Chinese obstructive sleep apnea (OSA) patients based on polysomnography (PSG) records.
We studied 2360 patients with OSA and 764 primary snorers who underwent PSG in our hospital. SE was divided into three grades, including ≥85%, 80%~84.9%, and <80%. Hypertension was defined based either on direct blood pressure measurements, under anti-hypertensive treatments or on physician diagnosis. Multivariate logistic regression models were conducted to investigate the association between SE and hypertension.
After adjusting for potential confounding factors, OSA patients with <80% SE and those with 80% to 84.9% SE were significantly associated with the prevalence of hypertension (OR = 1.248, 95% CI 1.0181.531, =0.033; OR = 1.380, 95% CI 1.0401.832, =0.026). Compared to primary snorers, OSA combined with <85% SE increased the odds of hypertension. In stratified analysis by SE, risk of hypertension only in those with <80% SE was significantly different between OSA and primary snorers. Furthermore, this relationship between reduced SE and hypertension was evident especially in female, younger ages, obese, moderate and severe OSA patients. No significant relationship between reduced SE and hypertension was found in primary snores group.
We found that poor SE was correlated with the prevalence of hypertension in Chinese OSA patients, but not in those with primary snoring. Moreover, this relationship was evident especially in female, younger ages, obese, moderate and severe OSA patients.
基于多导睡眠图（PSG）记录，探讨中国阻塞性睡眠呼吸暂停（OSA）患者的睡眠效率（SE）与高血压患病率之间的关系。
我们研究了在我院接受PSG检查的2360例OSA患者和764例原发性打鼾者。SE分为三个等级，包括≥85%、80%~84.9%和<80%。高血压根据直接血压测量、正在接受抗高血压治疗或医生诊断来定义。采用多因素逻辑回归模型研究SE与高血压之间的关联。
在调整潜在混杂因素后，SE<80%的OSA患者和SE为80%至84.9%的患者与高血压患病率显著相关（比值比[OR]=1.248，95%置信区间[CI]为1.0181.531，P=0.033；OR=1.380，95%CI为1.0401.832，P=0.026）。与原发性打鼾者相比，OSA合并SE<85%增加了高血压的患病几率。在按SE分层分析中，仅SE<80%的患者中，OSA组和原发性打鼾者组之间高血压风险存在显著差异。此外，SE降低与高血压之间的这种关系在女性、年轻、肥胖、中度和重度OSA患者中尤为明显。在原发性打鼾者组中未发现SE降低与高血压之间存在显著关系。
我们发现，SE较差与中国OSA患者的高血压患病率相关，但与原发性打鼾患者无关。此外，这种关系在女性、年轻、肥胖、中度和重度OSA患者中尤为明显。
