Khamsai Sittichai, Mahawarakorn Pawornwan, Limpawattana Panita, Chindaprasirt Jarin, Sukeepaisarnjaroen Wattana, Silaruks Songkwan, Senthong Vichai, Sawunyavisuth Bundit, Sawanyawisuth Kittisak
Department of Medicine, Faculty of Medicine.
Department of Marketing, Faculty of Business Administration and Accountancy, Khon Kaen University, Khon Kaen, Thailand.
Multidiscip Respir Med. 2021 Sep 10;16(1):777. doi: 10.4081/mrm.2021.777. eCollection 2021 Jan 15.
In 2003, the JNC 7 reported obstructive sleep apnea (OSA) as a cause of secondary hypertension. The prevalence of OSA in hypertension ranges from 30-80%. There are limited data on the prevalence and risk factors of OSA in hypertensive patients. This study thus aimed to evaluate prevalence and clinical predictors of obstructive sleep apnea (OSA) in these patients.
This was a cross-sectional study and conducted at the hypertension clinic at Khon Kaen University's Srinagarind Hospital, Thailand. We enrolled patients with hypertension treated at the clinic. OSA was defined as apnea-hypopnea index of 5 events/hour or over according to cardiopulmonary monitoring. Patients whose hypertension was due to any other causes were excluded. The prevalence of OSA was calculated and risk factors for OSA were analyzed using multivariate logistic regression.
There were 726 hypertensive patients treated at the clinic. Out of those, 253 (34.8%) were randomly studied and categorized as either non-OSA (147 patients, 58.1%) or OSA (106 patients, 41.9%). There were four independent factors associated with OSA-induced hypertension: age, sex, history of snoring, and history of headache. Headache had an adjusted odds ratio (95% confidence interval) of 3.564 (95% confidence interval of 1.510, 8.411).
Age, male sex, history of snoring, and headache were independent predictors of hypertension caused by OSA.
2003年，美国国家高血压教育计划（JNC 7）报告阻塞性睡眠呼吸暂停（OSA）是继发性高血压的一个病因。高血压患者中OSA的患病率在30%至80%之间。关于高血压患者中OSA的患病率和危险因素的数据有限。因此，本研究旨在评估这些患者中阻塞性睡眠呼吸暂停（OSA）的患病率和临床预测因素。
这是一项横断面研究，在泰国孔敬大学诗里拉吉医院的高血压诊所进行。我们纳入了在该诊所接受治疗的高血压患者。根据心肺监测，OSA被定义为呼吸暂停低通气指数每小时5次及以上。因任何其他原因导致高血压的患者被排除。计算OSA的患病率，并使用多因素逻辑回归分析OSA的危险因素。
该诊所有726名高血压患者接受治疗。其中，253名（34.8%）被随机纳入研究，并分为非OSA组（147名患者，58.1%）或OSA组（106名患者，41.9%）。有四个独立因素与OSA引起的高血压相关：年龄、性别、打鼾史和头痛史。头痛的调整优势比（95%置信区间）为3.564（95%置信区间为1.510, 8.411）。
年龄、男性、打鼾史和头痛是OSA所致高血压的独立预测因素。
