Su Huina, Li Huiling, Zhang Hua, Yang Xin, Wang Chaohua
Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.
Clinical Epidemiology Research Center, Peking University Third Hospital, Beijing, China.
Front Psychiatry. 2023 Feb 28;14:1050959. doi: 10.3389/fpsyt.2023.1050959. eCollection 2023.
To assess the severity of menopausal symptoms and the correlation among different quality of life questionnaires and compare the quality of life of patients who underwent hematopoietic stem cell transplantation (HSCT) for hematological disorders with the norm group in order to facilitate personalized and directed therapeutic intervention for patients.
We recruited women who had premature ovarian failure (POF) after HSCT for hematologic diseases in the gynecological endocrinology outpatient clinic of Peking University People's Hospital. Women with HSCT were included in the study if they had 6 months of spontaneous amenorrhea with serum follicle-stimulating hormone levels greater than 40 mIU/mL taken 4 weeks apart. The patients who had other causes of POF were excluded. During the survey, all women were required to fill out the questionnaires [Quality of Life Questionnaire (MENQOL), Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and 36-item Short-Form (SF-36)] online. We analyzed the severity of menopausal symptoms, anxiety, and depression in Participants. In addition, differences on the SF-36 scale scores between the study group and norm groups were examined.
In total, 227 (93.41%) patients completed the survey and were analyzed. The severity of all symptoms is "none and mild" in MRS, MENQOL, GAD-7, and PHQ-9. On the MRS, the most common symptoms were irritability, physical and mental exhaustion, and sleep problems. The severest symptoms were sexual problems (53, 73.82%), followed by sleep problems (44, 19.38%) and mental and physical exhaustion (39, 17.18%). In the MENQOL, the most common symptoms were psychosocial and physical symptoms. The severest symptoms were sexual symptoms (35, 48.75%) followed by psychosocial symptoms (23, 10.13%). Moderate-severe scores were shown in 11.89% (27) and 18.72% (42) cases in the GAD-7 and PHQ-9, respectively. Based on SF-36, in comparison with the norm group, the HSCT participants had higher vitality scores and lower role physical, physical functioning, and role emotional scores aged 18-45. In addition, the HSCT participants had lower mental health scores aged 18-25, and lower general health scores aged 25-45. No strong correlation was observed between questionnaires in our study.
Overall, menopausal symptoms are milder in female patients after HSCT. There is no single scale that comprehensively assesses the patient's quality of life after HSCT. We need to assess the severity of various symptoms in patients using different scales.
评估更年期症状的严重程度以及不同生活质量问卷之间的相关性，并比较因血液系统疾病接受造血干细胞移植（HSCT）的患者与正常组的生活质量，以便为患者提供个性化和有针对性的治疗干预。
我们在北京大人民医院妇科内分泌门诊招募了因血液系统疾病接受HSCT后出现卵巢早衰（POF）的女性。如果HSCT女性患者有6个月的自然闭经，且相隔4周测得的血清促卵泡激素水平大于40 mIU/mL，则纳入研究。排除有其他POF原因的患者。在调查期间，所有女性都被要求在线填写问卷[生活质量问卷（MENQOL）、广泛性焦虑障碍量表-7（GAD-7）、患者健康问卷-9（PHQ-9）和36项简短健康调查（SF-36）]。我们分析了参与者更年期症状、焦虑和抑郁的严重程度。此外，还检查了研究组与正常组在SF-36量表得分上的差异。
共有227名（93.41%）患者完成调查并进行分析。在MRS、MENQOL、GAD-7和PHQ-9中，所有症状的严重程度均为“无及轻度”。在MRS中，最常见的症状是易怒、身心疲惫和睡眠问题。最严重的症状是性功能问题（53例，73.82%），其次是睡眠问题（44例，19.38%）和身心疲惫（39例，17.18%）。在MENQOL中，最常见的症状是心理社会和身体症状。最严重的症状是性症状（35例，48.75%），其次是心理社会症状（23例，10.13%）。GAD-7和PHQ-9中分别有11.89%（27例）和18.72%（42例）的病例表现为中度至重度得分。基于SF-36，与正常组相比，18至45岁的HSCT参与者活力得分较高，而角色身体、身体功能和角色情感得分较低。此外，18至25岁的HSCT参与者心理健康得分较低，25至45岁的参与者总体健康得分较低。在我们的研究中，问卷之间未观察到强相关性。
总体而言，HSCT后女性患者的更年期症状较轻。没有单一的量表能全面评估HSCT后患者的生活质量。我们需要使用不同的量表评估患者各种症状的严重程度。
