Department of Neurosurgery, IMS and SUM Hospital, Bhubaneswar, Odisha, India.
Department of Microbiology, IMS and SUM Hospital, Bhubaneswar, Odisha, India.
Int J Mycobacteriol. 2023 Jan-Mar;12(1):107-109. doi: 10.4103/ijmy.ijmy_238_22.
Tuberculosis (TB) of the central nervous system accounts for only 1% of all cases of TB but 50% of these occur in the spine. Common clinical manifestations of spinal TB include fever, weight loss, back pain, lower limb weakness (either upper or lower motor neuron), and skeletal deformities such as kyphosis or gibbus. Infective pathology caused by Mycobacterium tuberculosis with epidural collection can present as acute cauda equina syndrome. Here, we describe a 28-year-old female patient who presented with low back pain and ascending weakness of both lower limbs (Medical Research Council grade 4/5 with absent ankle reflex) for 2 months with sudden-onset loss of bladder and bowel control for 1 day without any localized spinal tenderness, swelling, or discharging sinus in the back. Magnetic resonance imaging (MRI) spine was suggestive of an intraosseous collection with spondylodiscitis at the L4 level vertebral level. MRI can help identify the involvement of the vertebral bodies on either side of the disk, disk destruction, cold abscess, vertebral collapse, and the presence of vertebral column deformities making it a sensitive tool for the detection of spinal TB. Antituberculous treatment remains the cornerstone of treatment. Surgery is required in selected cases, for example, large abscess formation, severe kyphosis, an evolving neurological deficit, or lack of response to medical treatment. A combined intervention of laminectomy with drainage of the collection with antitubercular therapy after microbiological evidence helped in the resolution of the patient's condition. Early diagnosis and appropriate treatment generally result in a good prognosis.
中枢神经系统结核(TB)仅占所有 TB 病例的 1%,但其中 50%发生在脊柱。脊柱 TB 的常见临床表现包括发热、体重减轻、背痛、下肢无力(上或下运动神经元)以及脊柱后凸或侧凸等骨骼畸形。由结核分枝杆菌引起的感染性病理学伴有硬膜外积液可表现为急性马尾综合征。在这里,我们描述了一位 28 岁女性患者,她因 2 个月来出现腰痛和双下肢进行性无力(下肢运动神经 4/5 级,踝反射消失),1 天前突然出现膀胱和肠道失控,无背部任何局部脊柱压痛、肿胀或窦道。脊柱 MRI 提示 L4 水平椎骨水平存在骨内积液伴椎间盘炎。MRI 有助于识别椎间盘两侧的椎体受累、椎间盘破坏、冷脓肿、椎体塌陷以及脊柱畸形的存在,使其成为检测脊柱 TB 的敏感工具。抗结核治疗仍然是治疗的基石。在某些情况下需要手术,例如形成大脓肿、严重后凸畸形、进行性神经功能缺损或对药物治疗无反应。在微生物学证据支持下,通过椎板切除术联合引流和抗结核治疗的联合干预有助于患者病情的缓解。早期诊断和适当治疗通常会有较好的预后。