Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science & Technology, Soochow University, Suzhou 215123, China.
Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
ACS Macro Lett. 2023 Apr 18;12(4):428-432. doi: 10.1021/acsmacrolett.2c00761. Epub 2023 Mar 16.
Polymer coatings with improved surface antibacterial properties are of great importance for the application and development of implantable medical devices. Herein, we report the design, preparation, and antibacterial properties of a series of brush polymers (Dex-KEs) with hydrophilic dextran main-chains and mixed-charge polypeptide (KE) side-chains. Dex-KEs showed higher bactericidal activity and antifouling and antibiofilm properties than maleic acid modified dextran (Dex-Ma), KE, Dex-Ma/KE blend coatings, and brush polymer coatings with hydrophobic main-chains (AcDex-KEs). They also showed negligible cytotoxicity toward different mammalian cells and good biocompatibility. Dex-KE-coated implants exhibited potent resistance to bacterial infection before or after implantation.
具有改进的表面抗菌性能的聚合物涂层对于可植入医疗器械的应用和发展非常重要。在此，我们报告了一系列具有亲水性葡聚糖主链和混合电荷多肽（KE）侧链的刷状聚合物（Dex-KEs）的设计、制备和抗菌性能。与马来酸改性葡聚糖（Dex-Ma）、KE、Dex-Ma/KE 共混涂层以及具有疏水性主链的刷状聚合物涂层（AcDex-KEs）相比，Dex-KEs 具有更高的杀菌活性、抗污和抗生物膜性能。它们对不同的哺乳动物细胞也表现出可以忽略不计的细胞毒性和良好的生物相容性。在植入前后，Dex-KE 涂层的植入物表现出很强的抗细菌感染能力。
