Küçükkasap Cömert Tuğba, Muşlu Özlem, Ağagündüz Duygu
Department of Nutrition and Dietetics. Gülhane Faculty of Health Sciences. Sağlık Bilimleri Üniversitesi (University of Health Sciences).
Department of Nutrition and Dietetics. Faculty of Health Sciences. Yüksek İhtisas Üniversitesi.
Nutr Hosp. 2023 Apr 20;40(2):332-339. doi: 10.20960/nh.04487.
Introduction: food addiction is associated with genetic polymorphisms and decreased antioxidant intake. Objectives: this study determined the associations among food addiction, dopamine receptor 2 (DRD2) and toll-interleukin 1 receptor (TIR) domain-containing adaptor protein (TIRAP rs625413) gene polymorphisms, antioxidant capacities, and zinc levels among recreationally active Turkish women. Methods: the Yale Food Addiction Scale was used to evaluate the food addiction status. Serum antioxidant capacities and zinc levels were evaluated by blood analyses. Deoxyribonucleic acid (DNA) extraction was performed using peripheral blood leukocytes, and the polymorphism status of the DRD2 Taq 1A and TIRAP genes was investigated using a commercial kit. Results: the frequencies of the heterozygous genotypes of DRD2 Taq 1A and TIRAP were 23.1 % and 31.4 %, respectively, and the frequency of risk allele homozygous genotypes was 3.2 %. Most participants (94.4 %) had a nonpolymorphic/wild (CC) genotype in both genes; however, 11.5 % of the participants had a food addiction. The differences between serum antioxidant capacities, zinc levels, and body mass indices of those with and without food addiction were statistically significant. However, there were no differences in the serum zinc and antioxidant levels among the different genotypes. Conclusion: food addiction in young Turkish women was not associated with DRD2 Taq 1A or TIRAP polymorphisms but was associated with serum antioxidant capacities and zinc levels. Further studies on different loci of the same genes or genotypes of different genes with larger sample sizes are warranted.
食物成瘾与基因多态性及抗氧化剂摄入量降低有关。目的：本研究确定了在积极参与休闲活动的土耳其女性中，食物成瘾、多巴胺受体2（DRD2）和含Toll样白细胞介素1受体（TIR）结构域的衔接蛋白（TIRAP rs625413）基因多态性、抗氧化能力和锌水平之间的关联。方法：使用耶鲁食物成瘾量表评估食物成瘾状况。通过血液分析评估血清抗氧化能力和锌水平。使用外周血白细胞进行脱氧核糖核酸（DNA）提取，并使用商业试剂盒研究DRD2 Taq 1A和TIRAP基因的多态性状态。结果：DRD2 Taq 1A和TIRAP杂合基因型的频率分别为23.1%和31.4%，风险等位基因纯合基因型的频率为3.2%。大多数参与者（94.4%）在这两个基因中均具有非多态性/野生型（CC）基因型；然而，11.5%的参与者存在食物成瘾。有食物成瘾和无食物成瘾者的血清抗氧化能力、锌水平和体重指数之间的差异具有统计学意义。然而，不同基因型之间的血清锌和抗氧化水平没有差异。结论：年轻土耳其女性的食物成瘾与DRD2 Taq 1A或TIRAP多态性无关，但与血清抗氧化能力和锌水平有关。有必要对相同基因的不同位点或不同基因的基因型进行更大样本量的进一步研究。
