Department of Ophthalmology and Vision Science, the Eye & ENT Hospital of Fudan University, Shanghai, China.
Key Laboratory of Myopia, Ministry of Health, Shanghai, China.
Photobiomodul Photomed Laser Surg. 2023 Mar;41(3):104-119. doi: 10.1089/photob.2022.0120.
To evaluate relevant clinical outcomes and conclude possible mechanisms of intense pulsed light (IPL) in eyelid inflammation. IPL devices were primarily applied in cutaneous vascular malformations and have been used in ocular diseases for about 20 years, mostly including meibomian gland dysfunction (MGD), blepharitis, and ocular rosacea. Seventy-two original clinical researches were included, 57 for MGD, 4 for blepharitis or blepharitis-related keratoconjunctivitis, and 11 for rosacea. Dry eye symptoms, (tear) break-up time (BUT), and meibomian structure and/or functions were improved in most patients, but production of reactive oxygen species is an important link in the photobiomodulation mediated by IPL, which can influence numerous signal pathways to achieve anti-inflammatory, anti-infective, and prodifferentiation effects. The evidence suggests that IPL is an effective therapeutic tool for most patients with MGD, but more clinical evidence is needed for other indications.
评估强脉冲光（IPL）在眼睑炎症中的相关临床疗效，并总结可能的作用机制。IPL 设备最初主要应用于皮肤血管畸形，大约 20 年来已应用于眼部疾病，主要包括睑板腺功能障碍（MGD）、睑缘炎和眼部酒渣鼻。共纳入 72 项原始临床研究，其中 57 项用于 MGD，4 项用于睑缘炎或与睑缘炎相关的角结膜炎，11 项用于酒渣鼻。大多数患者的干眼症状、泪膜破裂时间（BUT）以及睑板腺结构和/或功能得到改善，但 IPL 介导的光生物调节中活性氧的产生是一个重要环节，它可以影响众多信号通路，从而达到抗炎、抗感染和促进分化的作用。有证据表明，IPL 是大多数 MGD 患者的有效治疗工具，但其他适应证还需要更多的临床证据。
