Yoon Hyeon-Jeong, Moon Ja Young, Yoon Kyung Chul
Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea.
Front Med (Lausanne). 2024 Sep 30;11:1454049. doi: 10.3389/fmed.2024.1454049. eCollection 2024.
Management of chalazion, characterized by noninfectious chronic granulomatous inflammation of the meibomian glands (MGs), remains challenging in ophthalmic practice, particularly because of its propensity for recurrence even after surgical intervention. This study aimed to evaluate the combined efficacy of doxycycline and intense pulsed light (IPL) therapy for treating intractable recurrent chalazion, focusing on reducing recurrence rates and improving MG status. This retrospective study included patients with intractable recurrent chalazion refractory to conventional treatments including surgical intervention and antibiotics. All patients were treated with a combination of doxycycline and IPL therapy. Clinical assessments included best-corrected visual activity, intraocular pressure, and MG evaluations using slit-lamp biomicroscopy and Keratograph 5 M topography. The study included 12 patients (5 male and 7 female) with an average age of 36.3 years. Treatment outcomes were categorized as 'success' (83.3%), 'stationary' (8.3%), and 'failure' (8.3%). Significant improvements were noted in the MG expression scores ( = 0.038), MG quality scores ( = 0.045), and lid margin telangiectasia scores ( = 0.002). In addition, significant improvement in meiboscores was observed ( = 0.002). The combination of doxycycline and IPL therapy demonstrated promising efficacy in treating intractable recurrent chalazion, with significant improvements in MG function and reduced recurrence rates. This treatment approach offers a viable alternative for patients with recurrent chalazions, particularly for those who are unresponsive to conventional treatments.
睑板腺囊肿的治疗颇具挑战性，其特征为睑板腺的非感染性慢性肉芽肿性炎症，尤其是即便经过手术干预后仍有复发倾向。本研究旨在评估强力霉素与强脉冲光（IPL）联合治疗难治性复发性睑板腺囊肿的疗效，重点关注降低复发率和改善睑板腺状态。这项回顾性研究纳入了对包括手术干预和抗生素在内的传统治疗无效的难治性复发性睑板腺囊肿患者。所有患者均接受强力霉素与IPL联合治疗。临床评估包括最佳矫正视力、眼压，以及使用裂隙灯生物显微镜和角膜地形图仪5M进行睑板腺评估。该研究纳入了12例患者（5例男性和7例女性），平均年龄为36.3岁。治疗结果分为“成功”（83.3%）、“稳定”（8.3%）和“失败”（8.3%）。睑板腺表达评分（P = 0.038）、睑板腺质量评分（P = 0.045）和睑缘毛细血管扩张评分（P = 0.002）均有显著改善。此外，睑板腺评分也有显著改善（P = 0.002）。强力霉素与IPL联合治疗在治疗难治性复发性睑板腺囊肿方面显示出有前景的疗效，睑板腺功能有显著改善且复发率降低。这种治疗方法为复发性睑板腺囊肿患者提供了一种可行的替代方案，特别是对于那些对传统治疗无反应的患者。
