School of Public Health, North China University of Science and Technology, Hebei Province, 063210, Tangshan, China.
School of Public Health, Baotou Medical College, Inner Mongolia, 014030, Baotou, China.
BMC Microbiol. 2023 Mar 16;23(1):74. doi: 10.1186/s12866-023-02801-4.
The pathogenesis of anti-tuberculosis (TB) drug-induced liver injury (ADLI) is complicated and remains unclear. We aimed to analyse the relationship between the characteristics of gut microbiota and ADLI in Mongolian and Han patients with pulmonary TB and identify the most notable bacteria related to the occurrence of liver injury in those populations.
Patients with concurrent liver injury (LI) and no liver injury (ULI) before receiving first-line anti-TB drug treatment (T1) from the Han population in Tangshan and the Mongolian population in Inner Mongolia were selected as research subjects. At the time of liver injury (T2), stool samples were measured by bacterial 16S rRNA gene high-throughput sequencing to analyse and compare the differences in the gut microbiota of the LI and ULI Mongolian and Han patients at T1 and T2 and identify the differences between those patients.
A total of 45 Mongolian and 37 Han patients were enrolled in our study. A dynamic comparison from T1 to T2 showed that the microbiota of the LI and ULI groups changed significantly from T1 to T2 in both the Mongolian and Han populations. However, there were commonalities and personality changes in the microbiota of the two ethnic groups.
Differences in gut microbes in ADLI were found among the Han and Mongolian patients in our study. Ekmania and Stenotrophomonas were related to the occurrence of ADLI in Mongolian patients, while Ekmania and Ruminococcus__gnavus_group were related to the occurrence of ADLI in the Han population.
抗结核（TB）药物性肝损伤（ADLI）的发病机制复杂，尚不清楚。我们旨在分析蒙古和汉族肺结核患者肠道微生物群特征与 ADLI 的关系，并确定与这两个人群肝损伤发生最相关的最显著细菌。
选择来自唐山汉族人群和内蒙古蒙古族人群的一线抗结核药物治疗前合并肝损伤（LI）和无肝损伤（ULI）的患者作为研究对象。在肝损伤时（T2），通过细菌 16S rRNA 基因高通量测序测量粪便样本，以分析和比较 T1 时 LI 和 ULI 蒙古和汉族患者肠道微生物群的差异，并确定这些患者之间的差异。
本研究共纳入 45 例蒙古族和 37 例汉族患者。从 T1 到 T2 的动态比较显示，LI 和 ULI 组的微生物群在蒙古族和汉族人群中均从 T1 到 T2 发生了显著变化。然而，两组的微生物群存在共性和个性变化。
本研究发现汉族和蒙古族 ADLI 患者的肠道微生物群存在差异。在蒙古族患者中，Ekmania 和 Stenotrophomonas 与 ADLI 的发生有关，而在汉族人群中，Ekmania 和 Ruminococcus__gnavus_group 与 ADLI 的发生有关。
