Department of Gastroenterology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing, China.
Department of Gastroenterology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing, China
BMJ Open. 2023 Mar 16;13(3):e050476. doi: 10.1136/bmjopen-2021-050476.
Chronic gastritis is a common disease worldwide. Studies have consistently shown that chronic gastritis is usually associated with gastric microbial dysbiosis, especially the infection of . However, the interaction between and non- bacteria in patients with chronic gastritis has not been clearly identified yet. Consequently, we designed a protocol for a systematic review and meta-analysis, which focused on identifying the changes in gastrointestinal microbiota composition between patients with -infective and non-infective chronic gastritis.
We will search PubMed, EMBASE and Cochrane Library databases to retrieve observational studies on humans. The eligible studies must include data about the relative abundance of the gastrointestinal microbiome in patients with -infective or non-infective chronic gastritis. Only the data of adults aged over 18 years will be analysed. Two researchers will extract the data independently, and Newcastle-Ottawa Scale will be used to assess the risk of bias. Random-effects model will be performed in quantitative analyses. Correlation analysis, bioinformatics analysis and function analysis will be performed.
Currently, numerous studies have revealed the role of in chronic gastritis. However, the alterations of non- bacteria in patients with chronic gastritis remain an open question. The results of our study might provide new insights into future diagnosis and treatments.
This study is based on published documents, unrelated to personal data, so ethical approval is not in need. The results of this study are expected to be published in journals or conference proceedings.
CRD42020205260; Pre-results.
慢性胃炎是一种全球性的常见病。研究一致表明，慢性胃炎通常与胃微生物失调有关，特别是感染。然而，慢性胃炎患者中与非细菌的相互作用尚未明确。因此，我们设计了一项系统评价和荟萃分析的方案，旨在确定感染和非感染性慢性胃炎患者胃肠道微生物群落组成的变化。
我们将检索 PubMed、EMBASE 和 Cochrane Library 数据库，以获取关于人类的观察性研究。合格的研究必须包括关于感染和非感染性慢性胃炎患者胃肠道微生物组相对丰度的数据。仅分析年龄在 18 岁以上的成年人的数据。两名研究人员将独立提取数据，并使用 Newcastle-Ottawa 量表评估偏倚风险。将进行定量分析的随机效应模型。将进行相关性分析、生物信息学分析和功能分析。
目前，许多研究已经揭示了在慢性胃炎中的作用。然而，慢性胃炎患者中非细菌的变化仍然是一个悬而未决的问题。我们的研究结果可能为未来的诊断和治疗提供新的见解。
本研究基于已发表的文献，与个人数据无关，因此不需要伦理批准。预计本研究的结果将发表在期刊或会议论文集中。
PROSPERO 注册号：CRD42020205260；预结果。
