Addissouky Tamer A, Wang Yuliang, Sayed Ibrahim El Tantawy El, Naser Naser A, Jalal AlAhmed Mohammed
Department of Biochemistry, Science Faculty, AL-Mustaqbal University, 51001, Hillah, Babylon, Iraq.
Biochemistry Branch, Department of Chemistry, Science Faculty, Menoufia University, Menoufia, Egypt.
Probiotics Antimicrob Proteins. 2025 Aug 12. doi: 10.1007/s12602-025-10706-z.
Helicobacter pylori (H. pylori) is a common gastrointestinal pathogen that can persist for decades and lead to diseases like gastritis, peptic ulcers, and gastric cancer. Conventional antibiotic treatments have limitations like resistance and side effects, requiring alternative therapies. The gut microbiota may influence H. pylori colonization and eradication success. Strategies like probiotics, prebiotics, diet, and lifestyle changes may modulate the gut microbiota composition and function to inhibit H. pylori growth. Specific probiotic strains produce antimicrobial compounds, modulate immune responses, and alter gut microbiota in ways that can promote H. pylori eradication. Diets high in fiber, polyphenols, omega-3s, and fermented foods appear to inhibit H. pylori by supporting growth of beneficial bacteria. Lifestyle factors like stress, smoking, and alcohol negatively impact the gut microbiota. Personalized therapies based on the gut microbiome could optimize eradication rates.
The gut microbiota represents a promising target for enhancing H. pylori eradication. Further research on microbiota-modulating therapies like probiotics, diet, and lifestyle changes may help develop more effective, personalized treatment approaches.
幽门螺杆菌是一种常见的胃肠道病原体，可长期存在数十年，并导致胃炎、消化性溃疡和胃癌等疾病。传统抗生素治疗存在耐药性和副作用等局限性，需要替代疗法。肠道微生物群可能影响幽门螺杆菌的定植和根除成功率。益生菌、益生元、饮食和生活方式改变等策略可能调节肠道微生物群的组成和功能，以抑制幽门螺杆菌生长。特定的益生菌菌株会产生抗菌化合物、调节免疫反应，并以促进幽门螺杆菌根除的方式改变肠道微生物群。富含纤维、多酚、ω-3脂肪酸和发酵食品的饮食似乎通过支持有益细菌的生长来抑制幽门螺杆菌。压力、吸烟和饮酒等生活方式因素会对肠道微生物群产生负面影响。基于肠道微生物组的个性化疗法可以优化根除率。
肠道微生物群是提高幽门螺杆菌根除率的一个有前景的靶点。对益生菌、饮食和生活方式改变等微生物群调节疗法的进一步研究可能有助于开发更有效、个性化的治疗方法。
