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影响老年人接种流感、肺炎球菌和带状疱疹疫苗的因素:基于人群的英格兰横断面研究。

Factors influencing influenza, pneumococcal and shingles vaccine uptake and refusal in older adults: a population-based cross-sectional study in England.

机构信息

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

出版信息

BMJ Open. 2023 Mar 16;13(3):e058705. doi: 10.1136/bmjopen-2021-058705.

Abstract

OBJECTIVES

Uptake of influenza, pneumococcal and shingles vaccines in older adults vary across regions and socioeconomic backgrounds. In this study, we study the coverage and factors associated with vaccination uptake, as well as refusal in the unvaccinated population and their associations with ethnicity, deprivation, household size and health conditions.

DESIGN, SETTING AND PARTICIPANTS: This is a cross-sectional study of adults aged 65 years or older in England, using a large primary care database. Associations of vaccine uptake and refusal in the unvaccinated with ethnicity, deprivation, household size and health conditions were modelled using multivariable logistic regression.

OUTCOME MEASURE

Influenza, pneumococcal and shingles vaccine uptake and refusal (in the unvaccinated).

RESULTS

This study included 2 054 463 patients from 1318 general practices. 1 711 465 (83.3%) received at least one influenza vaccine, 1 391 228 (67.7%) pneumococcal vaccine and 690 783 (53.4%) shingles vaccine. Compared with White ethnicity, influenza vaccine uptake was lower in Chinese (OR 0.49; 95% CI 0.45 to 0.53), 'Other ethnic' groups (0.63; 95% CI 0.60 to 0.65), black Caribbean (0.68; 95% CI 0.64 to 0.71) and black African (0.72; 95% CI 0.68 to 0.77). There was generally lower vaccination uptake among more deprived individuals, people living in larger household sizes (three or more persons) and those with fewer health conditions. Among those who were unvaccinated, higher odds of refusal were associated with the black Caribbean ethnic group and marginally with increased deprivation, but not associated with higher refusal in those living in large households or those with lesser health conditions.

CONCLUSION

Certain ethnic minority groups, deprived populations, large households and 'healthier' individuals were less likely to receive a vaccine, although higher refusal was only associated with ethnicity and deprivation but not larger households nor healthier individuals. Understanding these may inform tailored public health messaging to different communities for equitable implementation of vaccination programmes.

摘要

目的

老年人对流感、肺炎球菌和带状疱疹疫苗的接种率因地区和社会经济背景而异。本研究旨在研究接种率以及未接种人群的接种和拒绝接种的因素,并探讨其与种族、贫困、家庭规模和健康状况的关联。

设计、地点和参与者:这是一项在英格兰的老年人(65 岁及以上)中进行的横断面研究,使用了一个大型初级保健数据库。使用多变量逻辑回归模型,对疫苗接种和未接种人群的疫苗接种和拒绝接种(未接种)与种族、贫困、家庭规模和健康状况的关联进行了分析。

结果

本研究共纳入了来自 1318 个全科医生诊所的 2054463 名患者。1711465 名(83.3%)患者至少接种了一剂流感疫苗,1391228 名(67.7%)患者接种了肺炎球菌疫苗,690783 名(53.4%)患者接种了带状疱疹疫苗。与白人种族相比,中国人(比值比 0.49;95%置信区间 0.45 至 0.53)、“其他种族”群体(0.63;95%置信区间 0.60 至 0.65)、加勒比黑人和非洲黑人(0.68;95%置信区间 0.64 至 0.71)的流感疫苗接种率较低。经济条件较差、居住在大家庭(三人或以上)的人群和健康状况较差的人群的疫苗接种率普遍较低。在未接种疫苗的人群中,与加勒比黑人种族相关的拒绝接种疫苗的几率较高,与贫困程度略有相关,但与居住在大家庭或健康状况较差的人群的较高拒绝接种疫苗的几率无关。

结论

某些少数族裔群体、贫困人群、大家庭和“更健康”的个体更有可能不接种疫苗,尽管较高的拒绝接种率仅与种族和贫困程度相关,而与大家庭或健康状况较差的个体无关。了解这些因素可能有助于针对不同社区制定有针对性的公共卫生宣传信息,以公平地实施疫苗接种计划。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5092/10030484/cb9cbb8582cc/bmjopen-2021-058705f01.jpg

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