Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
National Heart and Lung Institute, Imperial College London, London, United Kingdom.
PLoS One. 2023 Mar 16;18(3):e0277588. doi: 10.1371/journal.pone.0277588. eCollection 2023.
To explore the link between COVID-19 incidence, socio-economic covariates, and NHL incidence.
Ecological study design.
Sardinia, Italy.
We used official reports on the total cases of COVID-19 in 2020, published data on NHL incidence, and socio-economic indicators by administrative unit, covering the whole regional population.
We used multivariable regression analysis to explore the association between the natural logarithm (ln) of the 2020 cumulative incidence of COVID-19 and the ln-transformed NHL incidence in 1974-2003, weighing by population size and adjusting by socioeconomic deprivation and other covariates.
The cumulative incidence of COVID-19 increased in relation to past incidence of NHL (p < 0.001), socioeconomic deprivation (p = 0.006), and proportion of elderly residents (p < 0.001) and decreased with urban residency (p = 0.001). Several sensitivity analyses confirmed the finding of an association between COVID-19 and NHL.
This ecological study found an ecological association between NHL and COVID-19. If further investigation would confirm our findings, shared susceptibility factors should be investigated among the plausible underlying mechanisms.
探索 COVID-19 发病率、社会经济协变量与 NHL 发病率之间的联系。
生态研究设计。
意大利撒丁岛。
我们使用了 2020 年 COVID-19 总病例的官方报告、发表的 NHL 发病率数据以及按行政单位划分的社会经济指标，覆盖了整个地区的人口。
我们使用多变量回归分析，探索 2020 年 COVID-19 累积发病率的自然对数（ln）与 1974-2003 年 NHL 发病率的 ln 变换之间的关联，按人口规模加权，并调整社会经济剥夺和其他协变量。
COVID-19 的累积发病率与 NHL 的既往发病率（p < 0.001）、社会经济剥夺（p = 0.006）、老年居民比例（p < 0.001）呈正相关，与城市居住呈负相关（p = 0.001）。几项敏感性分析证实了 COVID-19 与 NHL 之间存在关联。
这项生态研究发现 NHL 与 COVID-19 之间存在生态关联。如果进一步的调查能够证实我们的发现，那么应该在可能的潜在机制中调查共同的易感性因素。
