Hu Shasa, Federman Daniel G, Ma Fangchao, Kirsner Robert S
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine/Veterans Administration Medical Center, Miami, Florida 33125, USA.
Dermatol Surg. 2005 Jan;31(1):76-82. doi: 10.1111/j.1524-4725.2005.31013.
The incidence rates of melanoma and non-Hodgkin's lymphoma (NHL) have increased substantially worldwide over the past several decades. It has been hypothesized that ultraviolet light exposure through sunlight may be a common environmental risk factor shared by both skin cancer and NHL.
The purpose of this study was to better understand the association between skin cancer and NHL and to evaluate its implication in clinical practice.
We reviewed the current literature on the link between the two malignancies and on the role of ultraviolet light in the development of NHL. Publications were selected using a PUBMED search with the terms "non-Hodgkin's lymphoma" and "skin cancer." Epidemiologic studies in English and published after 1995 were the focus.
Large population-based studies support an increased risk of subsequent NHL among patients with skin cancers (both melanoma and nonmelanoma skin cancers) and a risk of skin cancer development in patients with NHL, although support for a direct relationship between ultraviolet light and the incidence of NHL is weak and inconsistent. Given their increased risk of developing skin cancers, patients with a history of NHL may benefit from a full-body examination during their visits.
在过去的几十年里，黑色素瘤和非霍奇金淋巴瘤（NHL）的发病率在全球范围内大幅上升。据推测，阳光中的紫外线照射可能是皮肤癌和NHL共同的常见环境风险因素。
本研究的目的是更好地了解皮肤癌与NHL之间的关联，并评估其在临床实践中的意义。
我们回顾了关于这两种恶性肿瘤之间联系以及紫外线在NHL发生发展中作用的当前文献。使用PUBMED搜索引擎，以“非霍奇金淋巴瘤”和“皮肤癌”为关键词筛选出版物。重点是1995年后发表的英文流行病学研究。
基于人群的大型研究支持皮肤癌患者（包括黑色素瘤和非黑色素瘤皮肤癌患者）后续发生NHL的风险增加，以及NHL患者发生皮肤癌的风险增加，尽管紫外线与NHL发病率之间存在直接关系的证据薄弱且不一致。鉴于有NHL病史的患者患皮肤癌的风险增加，他们在就诊期间可能受益于全身检查。
