Institute of Neurology, National Clinical Research Center for Infectious Diseases, the Third People's Hospital of Shenzhen, Shenzhen, China.
Department of Hepatology, National Clinical Research Center for Infectious Diseases, the Third People's Hospital of Shenzhen, Shenzhen, China.
Biosci Trends. 2023 May 15;17(2):85-116. doi: 10.5582/bst.2023.01039. Epub 2023 Mar 14.
Over three years have passed since the COVID-19 pandemic started. The dangerousness and impact of COVID-19 should definitely not be ignored or underestimated. Other than the symptoms of acute infection, the long-term symptoms associated with SARS-CoV-2 infection, which are referred to here as "sequelae of long COVID (LC)", are also a conspicuous global public health concern. Although such sequelae were well-documented, the understanding of and insights regarding LC-related sequelae remain inadequate due to the limitations of previous studies (the follow-up, methodological flaws, heterogeneity among studies, etc.). Notably, robust evidence regarding diagnosis and treatment of certain LC sequelae remain insufficient and has been a stumbling block to better management of these patients. This awkward situation motivated us to conduct this review. Here, we comprehensively reviewed the updated information, particularly focusing on clinical issues. We attempt to provide the latest information regarding LC-related sequelae by systematically reviewing the involvement of main organ systems. We also propose paths for future exploration based on available knowledge and the authors' clinical experience. We believe that these take-home messages will be helpful to gain insights into LC and ultimately benefit clinical practice in treating LC-related sequelae.
自 COVID-19 大流行开始以来，已经过去了三年。COVID-19 的危险性和影响绝对不容忽视或低估。除了急性感染的症状外，与 SARS-CoV-2 感染相关的长期症状，也被称为“长新冠后遗症 (LC)”，也是一个引人关注的全球公共卫生问题。尽管这些后遗症已经有详细的记录，但由于之前研究的局限性（随访、方法学缺陷、研究之间的异质性等），对 LC 相关后遗症的认识和见解仍然不足。值得注意的是，某些 LC 后遗症的诊断和治疗的有力证据仍然不足，这是更好地管理这些患者的绊脚石。这种尴尬的局面促使我们进行了这项研究。在这里，我们全面回顾了最新信息，特别是侧重于临床问题。我们试图通过系统地回顾主要器官系统的受累情况，提供与 LC 相关后遗症的最新信息。我们还根据现有知识和作者的临床经验，提出了未来探索的途径。我们相信，这些要点将有助于深入了解 LC，并最终有益于治疗 LC 相关后遗症的临床实践。
