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纸卡式电化学平台作为一种用于无创检测泪液中葡萄糖的智能即时检测设备。

Paper card-like electrochemical platform as a smart point-of-care device for reagent-free glucose measurement in tears.

作者信息

Fiore Luca, Sinha Ankita, Seddaoui Narjiss, di Biasio Jessica, Ricci Federico, Stojanovic Goran M, Arduini Fabiana

机构信息

Department of Chemical Science and Technologies, University of Rome ''Tor Vergata'', via della Ricerca Scientifica 1, Rome 00133, Italy.

SENSE4MED, Via Bitonto 139, Rome 00133, Italy.

出版信息

Chem Commun (Camb). 2023 Apr 6;59(29):4300-4303. doi: 10.1039/d2cc06561d.

DOI:10.1039/d2cc06561d
PMID:36928485
Abstract

This communication describes the development of polyvinyl chloride electrochemical system in which a paper layer loaded with reagents is inserted into the device, demonstrating a new concept of a paper card-like pad for a reagent-free and easy measurement of the target analyte in solution. This device detects glucose in artificial tears in the range of 0.2-2 mM with a detection limit of 50 μM by simply adding the artificial tears to the paper card-like pad. The novel configuration goes beyond the state of the art, widening the application range of paper in the design of smart analytical devices.

摘要

本通讯介绍了一种聚氯乙烯电化学系统的开发,其中将负载试剂的纸层插入该装置,展示了一种用于无试剂且轻松测量溶液中目标分析物的纸卡状垫的新概念。通过简单地将人工泪液添加到纸卡状垫上,该装置可检测浓度范围为0.2 - 2 mM的人工泪液中的葡萄糖,检测限为50 μM。这种新颖的配置超越了现有技术水平,拓宽了纸在智能分析设备设计中的应用范围。

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