Mirzaluo Mahdi, Fereiduni Fateme, Taheri Moein, Modabberifar Mehdi
Department of Mechanical Engineering, Faculty of Engineering, Arak University, Arak, 38156-88349, Iran.
Eur Biophys J. 2023 Feb;52(1-2):81-90. doi: 10.1007/s00249-023-01642-3. Epub 2023 Mar 16.
The study of mechanical properties of tissues can be considered as biomarkers for early detection of cancer and help in new treatments. In this study, the Young's modulus of MCF-7 breast cancer tissue was extracted using atomic force microscopy (AFM) by measuring the interaction force of the sample and performing a simulation. The force-indentation depth diagram was plotted by averaging the experimental results. In this paper, the modulus of elasticity of breast cancer tissue has been extracted with complex models such as DMT, MD, BCP, and SUN. By comparing the experimental and theoretical results and by changing the amount of hypothetical Young's modulus in the spherical contact models, the Young's modulus of the cancer tissue is considered to be between 300 and 400 Pa. The geometry of the cell was also assumed to be spherical according to the images obtained by atomic force microscopy.
组织力学性能的研究可被视为癌症早期检测的生物标志物，并有助于新的治疗方法。在本研究中，通过测量样品的相互作用力并进行模拟，使用原子力显微镜（AFM）提取了MCF-7乳腺癌组织的杨氏模量。通过对实验结果进行平均绘制了力-压痕深度图。在本文中，已使用DMT、MD、BCP和SUN等复杂模型提取了乳腺癌组织的弹性模量。通过比较实验和理论结果，并通过改变球形接触模型中假设杨氏模量的量，认为癌组织的杨氏模量在300至400帕斯卡之间。根据原子力显微镜获得的图像，细胞的几何形状也被假定为球形。
