Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, 563000, China.
Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, 563000, China.
Magn Reson Chem. 2023 Jun;61(6):386-391. doi: 10.1002/mrc.5345. Epub 2023 Mar 25.
Two new sesquiterpenoids, dendroaduoid A (1) and dendroaduol (2), together with four known sesquiterpenoids were isolated from the stems of Dendrobium aduncum. Their structures were identified by HR-ESI-MS and NMR experiments, and the complete assignments of H and C NMR data for two new sesquiterpenoids were obtained by the aid of HSQC, HMBC, H- H COSY, NOESY, and ECD techniques. The cytotoxic effects of the isolated compounds on four tumor cell lines (HCT-116, HepG2, A549, and SW1990) were evaluated using MTT assay. Otherwise, the inhibitory activity of these six sesquiterpenoids on glycosidase was also evaluated.
从弯梗钗子股(Dendrobium aduncum)茎中分离得到了两个新的倍半萜类化合物，即弯梗钗子股 A(1)和弯梗钗子股醇(2)，以及四个已知的倍半萜类化合物。通过高分辨电喷雾质谱(HR-ESI-MS)和 NMR 实验鉴定了它们的结构，并通过 HSQC、HMBC、H-H COSY、NOESY 和 ECD 技术获得了两个新的倍半萜类化合物的 1 H 和 13 C NMR 数据的完整归属。采用 MTT 法评价了分离得到的化合物对 4 种肿瘤细胞株(HCT-116、HepG2、A549 和 SW1990)的细胞毒活性。此外，还评价了这 6 个倍半萜类化合物对糖苷酶的抑制活性。
