Wei Xin, Wang Dan, Xu Ziming, Liu Jiajia, Zhu Qizhi, Chen Qi, Tang Heng, Xu Weiping
Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, PR China.
University of Science and Technology of China, Hefei, 230026, PR China.
Heliyon. 2024 Sep 7;10(18):e37541. doi: 10.1016/j.heliyon.2024.e37541. eCollection 2024 Sep 30.
Dendrobium is a precious Chinese herbal medicine, which belongs to the genus Orchidaceae. Ancient records and modern pharmacological research show that Dendrobium has pharmacological effects such as anti-tumor, antioxidant regulating immunity and blood glucose, and anti-aging. Dendrobium contains polysaccharides, alkaloids, bibenzyl, sesquiterpenes, phenanthrene, polyphenols and other types of chemicals. Its pharmacological activity is closely related to these chemical components. For example, dendrobium extracts can achieve anti-tumor effects by inhibiting tumor cell proliferation and metastasis, promoting cell apoptosis and ferroptosis, or increasing cell sensitivity to chemotherapy drugs. It enhances immunity by regulating immune cell activity or cytokine release. In addition, it can alleviate neurodegenerative diseases by protecting nerve cells from apoptotic damage. In recent years, research reports on biologically active compounds in Dendrobium have shown a blowout growth, which makes us realize that it is meaningful to continuously update the research progress on the components and pharmacological regulatory mechanism of this traditional Chinese medicine. By classifying the collected chemical components according to different chemical structures and summarizing their pharmacological mechanisms, we investigated the current research progress of Dendrobium and provide a more comprehensive scientific foundation for the further development and clinical transformation of Dendrobium in the future.
石斛是一种珍贵的中药材，属于兰科植物。古代记载和现代药理研究表明，石斛具有抗肿瘤、抗氧化、调节免疫和血糖以及抗衰老等药理作用。石斛含有多糖、生物碱、联苄、倍半萜、菲类、多酚等多种化学成分。其药理活性与这些化学成分密切相关。例如，石斛提取物可通过抑制肿瘤细胞增殖和转移、促进细胞凋亡和铁死亡，或增加细胞对化疗药物的敏感性来实现抗肿瘤作用。它通过调节免疫细胞活性或细胞因子释放来增强免疫力。此外，它可以通过保护神经细胞免受凋亡损伤来缓解神经退行性疾病。近年来，关于石斛中生物活性化合物的研究报道呈井喷式增长，这使我们认识到不断更新对这种中药成分及药理调控机制的研究进展具有重要意义。通过根据不同化学结构对收集到的化学成分进行分类并总结其药理机制，我们对石斛的当前研究进展进行了调查，并为石斛未来的进一步开发和临床转化提供了更全面的科学依据。
