Liu Hong-Xin, Tan Hai-Bo, Chen Yu-Chan, Li Sai-Ni, Li Hao-Hua, Zhang Wei-Min
State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou, China.
Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China.
Nat Prod Res. 2020 Sep;34(17):2430-2436. doi: 10.1080/14786419.2018.1539977. Epub 2019 Jan 2.
The culture broth of sp. A593, which was isolated from , showed potent cytotoxicity against several human tumor cell lines. The following chemical study resulted in the isolation of two new triquinane-type sesquiterpenoids, named cerrenins D ( and E (), along with two known compounds plerocybellone A () and chloriolin B (). Their structures were fully assigned with the aid of extensive spectroscopic analysis (H and C NMR, HSQC, HMBC, H-H COSY, HRESIMS, and IR) and data from the literature. Moreover, cytotoxic activity of compounds - were evaluated against SF-268, MCF-7, NCI-H460, and HepG-2 tumor cell lines. The new compound exhibited weak growth inhibitory activity against all the four tumor cell lines with IC values of 41.01, 14.43, 29.67, 44.32 μM.
从[具体来源]分离得到的A593菌株的培养液对几种人类肿瘤细胞系显示出强大的细胞毒性。接下来的化学研究分离出了两种新的三环烷型倍半萜类化合物，分别命名为cerrenins D（[具体结构描述1]）和E（[具体结构描述2]），以及两种已知化合物plerocybellone A（[具体结构描述3]）和chloriolin B（[具体结构描述4]）。借助广泛的光谱分析（氢谱和碳谱核磁共振、异核单量子相干谱、异核多键相关谱、氢-氢化学位移相关谱、高分辨电喷雾电离质谱和红外光谱）以及文献数据，完全确定了它们的结构。此外，评估了化合物[具体化合物编号1]-[具体化合物编号4]对SF-268、MCF-7、NCI-H460和HepG-2肿瘤细胞系的细胞毒性活性。新化合物[具体化合物编号1]对所有四种肿瘤细胞系均表现出较弱的生长抑制活性，其半数抑制浓度值分别为41.01、14.43、29.67、44.32μM。
