College of Chemistry & Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, People's Republic of China.
Cheng'an County Hospital of Traditional Chinese Medicine, Handan, People's Republic of China.
J Biomed Mater Res B Appl Biomater. 2023 Aug;111(8):1499-1510. doi: 10.1002/jbm.b.35249. Epub 2023 Mar 16.
Currently, traditional cancer treatment strategies are greatly challenged by the existence of cancer stem cells (CSCs), which are root cause of chemotherapy resistance. Differentiation therapy presents a novel therapeutic strategy for CSC-targeted therapy. However, there are very few studies on the induction of CSCs differentiation so far. Silicon nanowire array (SiNWA) with many unique properties is considered to be an excellent material for various applications ranging from biotechnology to biomedical applications. In this study, we report the SiNWA differentiates MCF-7-derived breast CSCs (BCSCs) into non-CSCs by modulating the morphology of cells. In vitro, the differentiated BCSCs lose the stemness properties and thus become sensitive to chemotherapeutic drugs, eventually leading to the death of BCSCs. Therefore, this work suggests a potential approach for overcoming chemotherapeutic resistance.
目前，癌症干细胞（CSC）的存在极大地挑战了传统癌症治疗策略，因为 CSC 是化疗耐药性的根源。分化治疗为 CSC 靶向治疗提供了一种新的治疗策略。然而，目前关于 CSC 诱导分化的研究非常少。硅纳米线阵列（SiNWA）具有许多独特的性质，被认为是一种极好的材料，可应用于从生物技术到生物医学应用等各种领域。在这项研究中，我们报告了 SiNWA 通过调节细胞形态将 MCF-7 衍生的乳腺癌 CSC（BCSC）分化为非 CSC。在体外，分化后的 BCSC 失去了干性特征，因此对化疗药物敏感，最终导致 BCSC 死亡。因此，这项工作为克服化疗耐药性提供了一种潜在的方法。
