sBGC-hm：人类肠道微生物组中次生代谢物生物合成基因簇图谱。
sBGC-hm: an atlas of secondary metabolite biosynthetic gene clusters from the human gut microbiome.
机构信息
National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution, Wenzhou University, Wenzhou 325035, China.
Zhejiang Provincial Key Laboratory for Subtropical Water Environment and Marine Biological Resources Protection, Wenzhou University, Wenzhou 325035, China.
出版信息
Bioinformatics. 2023 Mar 1;39(3). doi: 10.1093/bioinformatics/btad131.
SUMMARY
Microbial secondary metabolites exhibit potential medicinal value. A large number of secondary metabolite biosynthetic gene clusters (BGCs) in the human gut microbiome, which exhibit essential biological activity in microbe-microbe and microbe-host interactions, have not been adequately characterized, making it difficult to prioritize these BGCs for experimental characterization. Here, we present the sBGC-hm, an atlas of secondary metabolite BGCs allows researchers to explore the potential therapeutic benefits of these natural products. One of its key features is the ability to assist in optimizing the BGC structure by utilizing the gene co-occurrence matrix obtained from Human Microbiome Project data. Results are viewable online and can be downloaded as spreadsheets.
AVAILABILITY AND IMPLEMENTATION
The database is openly available at https://www.wzubio.com/sbgc. The website is powered by Apache 2 server with PHP and MariaDB.
摘要
微生物次生代谢产物具有潜在的药用价值。人体肠道微生物组中存在大量的次生代谢产物生物合成基因簇（BGCs），这些 BGCs 在微生物-微生物和微生物-宿主相互作用中表现出重要的生物活性，但尚未得到充分的描述，这使得难以优先对这些 BGCs 进行实验表征。在这里，我们提出了 sBGC-hm，这是一个次生代谢产物 BGCs 图谱，允许研究人员探索这些天然产物的潜在治疗益处。它的一个关键特点是能够通过利用从人类微生物组计划数据中获得的基因共现矩阵来协助优化 BGC 结构。结果可以在线查看，并可以下载为电子表格。
可用性和实现
该数据库可在 https://www.wzubio.com/sbgc 上公开获取。该网站由 Apache 2 服务器提供支持，使用 PHP 和 MariaDB。
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